{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:18:31Z","timestamp":1787926711790,"version":"build-2784847793"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100019214","name":"l\u00e9ka\u0159sk\u00e1 fakulta Univerzity Karlovy","doi-asserted-by":"crossref","award":["Cooperatio Programme"],"award-info":[{"award-number":["Cooperatio Programme"]}],"id":[{"id":"10.13039\/100019214","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EU - Next Generation EU","award":["LX22NPO5104"],"award-info":[{"award-number":["LX22NPO5104"]}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"crossref","award":["IKEM, IN 00023001"],"award-info":[{"award-number":["IKEM, IN 00023001"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Early postoperative glycemic control after orthotopic liver transplantation (OLTx) is challenging because of surgical stress, corticosteroid and calcineurin-inhibitor immunosuppression, and parenteral nutrition. We evaluated whether adding real-time continuous glucose monitoring (rtCGM) to standard care increases time in the target glucose range.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this single-center randomized controlled trial, OLTx recipients were randomized after surgery to open (Active) or blinded (Control) rtCGM (Dexcom G6); in the Active group, sensor data guided insulin titration. The primary endpoint was time in target range (TIR, 6.0\u201310.0 mmol\/L), analyzed in a modified intention-to-treat population. Secondary endpoints included glycemic metrics, insulin requirements, and predefined clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We randomized 154 patients; 142 with available data were analyzed (82 Active, 60 Control). The Active group spent more time in target range (68.9% vs. 60.8%; median difference 7.2 percentage points [95% CI: 2.7\u201312.0];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003), with less time in Level 1 hyperglycemia (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.025) and fewer extended hyperglycemic episodes (incidence rate ratio 1.65 [1.03\u20132.65] for Control vs. Active;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.039). TIR improved similarly in patients with and without pretransplant diabetes; the only significant treatment-by-diabetes interaction was a greater reduction in Level 2 hyperglycemia among patients with diabetes (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Hypoglycemia was minimal in both groups. Infectious complications were less frequent in the Active group (45.1% vs. 63.3%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.041).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Adding rtCGM to standard postoperative care improved glycemic control after liver transplantation, with consistent benefit regardless of diabetes status and the greatest effect on Level 2 hyperglycemia in patients with diabetes. The lower infection rate is a hypothesis-generating finding warranting a dedicated trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15209156261480872","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:01:07Z","timestamp":1787634067000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-Time Continuous Glucose Monitoring Improves Glycemic Control in the Early Postoperative Period Following Liver Transplantation: A Randomized Controlled Trial"],"prefix":"10.1177","author":[{"given":"Marek","family":"Protus","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Resuscitation and Intensive Care, Institute for Clinical and Experimental Medicine, Prague, Czech Republic."},{"name":"First Faculty of Medicine, Charles University, Prague, Czech 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Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Beckova","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Resuscitation and Intensive Care, Institute for Clinical and Experimental Medicine, Prague, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Macek","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Resuscitation and Intensive Care, Institute for Clinical and Experimental Medicine, Prague, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Doleckova","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Mraz","sequence":"additional","affiliation":[{"name":"First Faculty of Medicine, Charles University, Prague, Czech Republic."},{"name":"Metabolic Intensive Care Unit of Transplantcentre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Haluzik","sequence":"additional","affiliation":[{"name":"First Faculty of Medicine, Charles University, Prague, Czech Republic."},{"name":"Department of Diabetes, Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Girman","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Viravova","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Resuscitation and Intensive Care, Institute for Clinical and 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