{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:54:45Z","timestamp":1791046485545,"version":"4.1.0"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Strategy for Patient-Oriented Research","award":["JT1-157204"],"award-info":[{"award-number":["JT1-157204"]}]},{"name":"Breakthrough T1D Canada","award":["4-SRA-2018-651-Q-R"],"award-info":[{"award-number":["4-SRA-2018-651-Q-R"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To assess continuous glucose monitoring (CGM) data corresponding to blood glucose (BG) values used for impending non-severe (NS) hypoglycemia management in people living with type 1 diabetes (PwTID).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We performed a secondary analysis of the REVERSIBLE trial, a three-arm open-label crossover study assessing the efficacy of 16 g oral carbohydrates (CHO) for preventing NS hypoglycemia at different BG levels: &lt;72 mg\/dL (4 mmol\/L, level 1), \u226480 mg\/dL (4.5 mmol\/L), or \u226490mg\/dL (5.0 mmol\/L). CGM data (DexcomG6\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) were compared with BG to assess their variances and mean absolute relative differences (MARDs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In all three arms CGM values overestimated BG levels (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). MARDs were higher with lower BG values. Despite these differences, we did not observe rebound hyperglycemia (BG &gt; 180 mg\/dL; 10 mmol\/L).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>When using CGM, PwTID may need to treat or prevent NS hypoglycemia at a higher threshold than 72 mg\/dL (4.0 mmol\/L) and 80 mg\/dL (4.5 mmol\/L), respectively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15209156261493676","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:29:13Z","timestamp":1790828953000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Blood Glucose Values Used for Impending Non-Severe Hypoglycemia Management with Corresponding Continuous Glucose Monitoring Data in Type 1 Diabetes: A Secondary Analysis of the REVERSIBLE Trial"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5776-6984","authenticated-orcid":false,"given":"Andr\u00e9anne","family":"Marquis","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Canada."},{"name":"Endocrinology Division, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Canada."},{"name":"Montreal Institute for Clinical research (IRCM), Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Al-Mahayni","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Canada."},{"name":"Cardiometabolic axis, Centre de recherche du centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Osman","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Canada."},{"name":"Cardiometabolic axis, Centre de recherche du centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Molveau","sequence":"additional","affiliation":[{"name":"Montreal Institute for Clinical research (IRCM), Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Messier","sequence":"additional","affiliation":[{"name":"Montreal Institute for Clinical research (IRCM), Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Rabasa-Lhoret","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Canada."},{"name":"Montreal Institute for Clinical research (IRCM), Montreal, Canada."},{"name":"Departement of Nutrition, Universit\u00e9 de Montr\u00e9al, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Taleb","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Canada."},{"name":"Endocrinology Division, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Canada."},{"name":"Montreal Institute for Clinical research (IRCM), Montreal, Canada."},{"name":"Cardiometabolic axis, Centre de recherche du centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2015.10.004"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2023.110822"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12020391"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-022-01987-9"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0133"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14528"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0150"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S006"},{"key":"e_1_3_3_11_1","article-title":"Diabetes Canada 2018 clinical practice guidelines for the prevention and management of Diabetes in Canada: Hypoglycemia in Adults","author":"Lega ICea","year":"2023","unstructured":"10.Lega ICea. Diabetes Canada 2018 clinical practice guidelines for the prevention and management of Diabetes in Canada: Hypoglycemia in Adults. Can J Diabetes 2023.","journal-title":"Can J Diabetes"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-1328"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2016.0112"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0143"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/19322968221099879"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/19322968251412482"}],"container-title":["Diabetes Technology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15209156261493676","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15209156261493676","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15209156261493676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:19:34Z","timestamp":1791044374000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15209156261493676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":15,"alternative-id":["10.1177\/15209156261493676"],"URL":"https:\/\/doi.org\/10.1177\/15209156261493676","relation":{},"ISSN":["1520-9156","1557-8593"],"issn-type":[{"value":"1520-9156","type":"print"},{"value":"1557-8593","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"article-number":"15209156261493676"}}