{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:47:07Z","timestamp":1791564427971,"version":"4.3.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"16-18","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      Obesity remains a major global health issue, with the increasing focus on the incretin hormone glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R) for therapeutic strategies. D-allulose is predicted to modulate GLP-1R\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      mechanisms linked to endoplasmic reticulum stress and reactive oxygen species (ROS) pathways, positively influencing GLP-1R stability and functionality. This study investigates the potential of D-allulose as a therapeutic and preventive agent against obesity. It focuses on the impact of D-allulose on adipocyte differentiation and obesity in high-fat diet (HFD)-administered and GLP-1R knockout (KO) mice over 12 weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      D-allulose effectively regulated adipocyte differentiation by inhibiting the NADP\n                      <jats:sup>+<\/jats:sup>\n                      \/NADPH-ROS-inositol-requiring enzyme 1\u03b1 (IRE1\u03b1)-regulated IRE1-dependent decay (RIDD) axis, resulting in controlled decay of GLP-1R, a newly identified RIDD target. Furthermore,\n                      <jats:italic toggle=\"yes\">in\u00a0vivo<\/jats:italic>\n                      studies revealed that D-allulose administration significantly regulated body weight and other obesity parameters in HFD-fed mice. However, these effects were not observed in GLP-1R KO mice, suggesting that the antiobesity effects of D-allulose rely on the presence of GLP-1R.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation and Conclusion:<\/jats:title>\n                    <jats:p>\n                      This study highlights the efficacy of D-allulose in controlling obesity through mechanisms dependent on GLP-1R, suggesting its potential as an effective treatment for obesity with normal GLP-1R function.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      43, 819\u2013832.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15230864251399183","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:33:07Z","timestamp":1764657187000},"page":"819-832","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["D-Allulose Regulates Obesity via Endoplasmic Reticulum Stress-Mediated Glucagon-Like Peptide-1 Receptor Pathway"],"prefix":"10.1177","volume":"43","author":[{"given":"Geum-Hwa","family":"Lee","sequence":"first","affiliation":[{"name":"Research Institute of Clinical Medicine of Jeonbuk, National University-Biomedical Research Institute of Jeonbuk, National University Hospital, Jeonju, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwa-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical Medicine of Jeonbuk, National University-Biomedical Research Institute of Jeonbuk, National University Hospital, Jeonju, Republic of Korea."},{"name":"Non-Clinical Evaluation Center Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jae","family":"Lim","sequence":"additional","affiliation":[{"name":"Non-Clinical Evaluation Center Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Non-Clinical Evaluation Center Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Young","family":"Rah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Jeonbuk National University Medical School, Jeonju, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Ja","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jeonbuk National University Medical School, Jeonju, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Young","family":"Park","sequence":"additional","affiliation":[{"name":"Food Biotech R&amp;D Center, Samyang Corp., Seongnam-si, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soonok","family":"Sa","sequence":"additional","affiliation":[{"name":"Food Biotech R&amp;D Center, Samyang Corp., Seongnam-si, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyewon","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jeonbuk National University, Jeonju, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjo","family":"Soh","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jeonbuk National University, Jeonju, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry, Jeonbuk National University, Jeonju, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Jung","family":"Chae","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical Medicine of Jeonbuk, National University-Biomedical Research Institute of Jeonbuk, National University Hospital, Jeonju, Republic of Korea."},{"name":"Non-Clinical Evaluation Center Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Republic of Korea."},{"name":"School of Pharmacy, Jeonbuk National University, Jeonju, Republic of 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