{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:26:41Z","timestamp":1788193601864,"version":"build-2803163510"},"reference-count":47,"publisher":"SAGE Publications","issue":"1-3","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Chongqing medical scientific research project","award":["2024GDRC005"],"award-info":[{"award-number":["2024GDRC005"]}]},{"name":"Chongqing medical scientific research project","award":["2024ZDXM033"],"award-info":[{"award-number":["2024ZDXM033"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82371098"],"award-info":[{"award-number":["82371098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate whether citicoline alleviates endoplasmic reticulum (ER) stress by modulating oxidative stress in myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A form-deprivation myopia model in guinea pigs and a hypoxia-induced model in human scleral fibroblasts revealed that citicoline downregulated cysteine dioxygenase 1 (CDO1) expression, increased glutathione, and reduced reactive oxygen species. These changes mitigated oxidative stress, suppressed ER stress, maintained cellular homeostasis, and inhibited extracellular matrix remodeling, leading to reduced axial elongation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>Transcriptomic profiling identified CDO1 as a novel downstream effector of citicoline, linking cysteine metabolism to oxidative and ER stress regulation in myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Citicoline shows potential to delay myopia progression by alleviating ER stress through CDO1-mediated redox regulation, providing preclinical mechanistic insight into its possible role in myopia control.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      45, 113\u2013132.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15230864261443857","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T01:54:02Z","timestamp":1776304442000},"page":"113-132","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Citicoline Restores Endoplasmic Reticulum Homeostasis by Regulating Oxidative Stress Through CDO1 to Reverse Myopia Progression"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1563-9469","authenticated-orcid":false,"given":"Peijuan","family":"Wu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on Major Blinding Diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National 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