{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:31:36Z","timestamp":1792096296221,"version":"4.4.0"},"reference-count":60,"publisher":"SAGE Publications","issue":"7-9","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sj\u00f6gren\u2019s syndrome (SS) is a systemic autoimmune disorder characterized by chronic inflammation, oxidative stress, and progressive salivary gland dysfunction. Current therapies remain limited in efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study explored the regulatory effect of exosome (Exo)-transported miR-23b-3p on the I\u03baB kinase alpha (IKK\u03b1)\/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-\u03baB) signaling axis in SS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Key SS-related microRNAs (miRNAs) were identified by integrating weighted gene co-expression network analysis with machine-learning-based transcriptomic profiling. Target genes and functional pathways were analyzed by bioinformatics methods. The direct binding between miR-23b and IKK\u03b1 (CHUK) was validated by a dual-luciferase reporter assay. An\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      SS cell model was established to examine the effects of miR-23b-3p on the IKK\u03b1\/NF-\u03baB pathway, oxidative stress, inflammation, and apoptosis. miR-23b-3p was loaded into salivary gland epithelial cell-derived Exos (SGEC-Exos)\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      electroporation.\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      coculture experiments assessed reactive oxygen species (ROS) levels, inflammatory cytokines, Treg\/Th17 balance, and cell apoptosis.\n                      <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                      effects were evaluated in NOD\/Ltj mice by measuring salivary flow rate, histopathology, and expression of salivary-function-related proteins AQP5 and GPER.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>SGEC-Exos@miR-23b-3p significantly suppressed IKK\u03b1 expression and NF-\u03baB activation, reduced ROS production, and modulated immune responses by restoring the Treg\/Th17 balance. It also inhibited apoptosis by decreasing Bax and caspase-3 expression and increasing Bcl-2 levels. These effects were partially reversed by reactivation of the IKK\u03b1\/NF-\u03baB pathway. In NOD\/Ltj mice, SGEC-Exos@miR-23b-3p improved salivary flow, alleviated glandular pathology, and upregulated AQP5 and GPER expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      SGEC-Exos@miR-23b-3p offers a translational approach to address oxidative stress, immune imbalance, and glandular injury in SS, highlighting the potential of Exo-based miRNA therapy.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      45, 376\u2013396.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15230864261443868","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:45:35Z","timestamp":1780969535000},"page":"376-396","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting the IKK\u03b1\/NF-\u03baB Axis with SGEC-Derived Exosomal miR-23b-3p Rebalances Treg\/Th17 Immunity in Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7794-6319","authenticated-orcid":false,"given":"Yan","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Hospital of Stomatology, Jilin University, Changchun, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"1nd ward of Oncology and Hematology Department, China-Japan Union Hospital of Jilin University, Changchun, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Hospital of Stomatology, Jilin University, Changchun, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyong","family":"E.","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"issue":"3","key":"e_1_3_3_2_1","first-page":"14","article-title":"One year in review 2018: Sj\u00f6gren\u2019s syndrome","volume":"36","author":"Argyropoulou OD","year":"2018","unstructured":"Argyropoulou OD, , Valentini E, , Ferro F, et al. One year in review 2018: Sj\u00f6gren\u2019s syndrome. Clin Exp Rheumatol 2018;36 Suppl 112(3):14\u201326.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2019.10.004"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2022.100582"},{"issue":"3","key":"e_1_3_3_5_1","first-page":"3","article-title":"One year in review 2019: Sj\u00f6gren\u2019s syndrome","volume":"37","author":"Cafaro G","year":"2019","unstructured":"Cafaro G, , Croia C, , Argyropoulou OD, et al. One year in review 2019: Sj\u00f6gren\u2019s syndrome. 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