{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:27:58Z","timestamp":1786523278953,"version":"build-2736575974"},"reference-count":24,"publisher":"SAGE Publications","issue":"10-12","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Medical and Health Talent Special Project of Yunnan Province under the \u201cSupport Program for Talents of Developing Yunnan\u201d"},{"name":"National Natural Science Foundation of China - Regional Science Foundation Project","award":["82360203"],"award-info":[{"award-number":["82360203"]}]},{"name":"Joint Special Project of Kunming Medical University","award":["202401AY070001-294"],"award-info":[{"award-number":["202401AY070001-294"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This study aimed to delineate a novel mechanistic axis linking hyperglycemia-driven glycolytic reprogramming to ferroptotic death in lens epithelial cells (LECs) and to determine its therapeutic significance in diabetic cataract (DC). Specifically, we sought to define the integration of metabolic, epigenetic (histone lactylation), and post-translational (fucosylation) pathways in DC pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Under hyperglycemic conditions, LECs exhibited robust glycolytic activation and lactate accumulation. This metabolic shift drove selective histone H3K18 lactylation at the promoter of theTSTA3 gene, leading to its increased transcription. The upregulated TSTA3 protein then promoted the core fucosylation of the NF-\u03baB p50 subunit, which facilitated its nuclear translocation. Inside the nucleus, p50 transcriptionally activatedNOX1, resulting in excessive reactive oxygen species (ROS) production and subsequent ferroptotic cell death. Critically, both pharmacological inhibition of glycolysis and genetic silencing ofTSTA3 effectively attenuated oxidative stress, restored redox balance, and ameliorated cataract severity in a diabetic rat model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>This work identifies a previously unrecognized pathogenic cascade\u2014the glycolysis\u2013histone lactylation\u2013fucosylation\u2013ferroptosis axis\u2014that directly links metabolic flux to epigenetic and signaling control in DC. By positioning TSTA3 as a central, druggable node within this axis, our study redefines cataract pathogenesis beyond simple oxidative damage, integrating multiple layers of cellular regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The glycolysis\u2013histone lactylation\u2013TSTA3\u2013fucosylation\u2013NOX1\u2013ferroptosis axis is a critical driver of LEC death in diabetic cataract. Targeting this newly defined pathway, particularly the TSTA3 node, offers novel opportunities for mechanism-based therapeutic interventions and biomarker development, with potential implications for other complications of metabolic disease.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      45, 474\u2013490.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15230864261463738","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:55:41Z","timestamp":1782698141000},"page":"474-490","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Histone Lactylation Links Glycolysis to Ferroptosis in Diabetic Cataract"],"prefix":"10.1177","volume":"45","author":[{"given":"Dan","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kunming Medical University Affiliated Children\u2019s Hospital, Kunming City, China."},{"name":"Yunnan Women and Children\u2019s Hospital, Kunming City, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kunming Medical University Affiliated Children\u2019s Hospital, Kunming City, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kunming Medical University Affiliated Children\u2019s Hospital, Kunming City, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kunming Medical University Affiliated Children\u2019s Hospital, Kunming City, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhong","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kunming Medical University Affiliated Children\u2019s Hospital, Kunming City, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kunming Medical University Affiliated Children\u2019s Hospital, Kunming City, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kunming Medical University Affiliated Children\u2019s Hospital, Kunming City, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5255-1734","authenticated-orcid":false,"given":"Ninghua","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First People\u2019s Hospital of Yunnan Province, Kunming City, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2544-7"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32832f802a"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108705"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13101249"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.10.323"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102201"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5060"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab362"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/608751"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.6.746"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-24353"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.10.005"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103627"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103194"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.12.021"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-021-00841-9"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-022-00198-w"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02776-z"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14742"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1678-1"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.48225"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-023-01427-4"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1614"}],"container-title":["Antioxidants &amp; 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