{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:51Z","timestamp":1792787691642,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"13-15","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Youth Medical Talent Training Program of the First Affiliated Hospital of Harbin Medical University","award":["Grant No.: 2024YQ25"],"award-info":[{"award-number":["Grant No.: 2024YQ25"]}],"id":[{"id":"https:\/\/ror.org\/05vy2sc54","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cerebral ischemia-reperfusion injury (CIRI) is a key contributor to stroke-related neurological damage, but the functional interplay between autophagy and ferroptosis\u2014two critical pathological processes\u2014remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Using oxygen-glucose deprivation\/reperfusion in PC12 cells and middle cerebral artery occlusion (MCAO) in rats, we combined molecular, pharmacological, and imaging approaches to investigate how autophagy regulates the ferroptosis suppressor acyl-CoA synthetase long-chain family member 3 (ACSL3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ischemia-reperfusion triggered hyperactivated autophagy, which promoted ferroptosis by selectively targeting ACSL3 for degradation\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      the autophagy receptor neighbor of BRCA1 gene 1 protein (NBR1). We further identified that tripartite motif-containing protein 33 (TRIM33), an E3 ubiquitin ligase induced after ischemia, directly ubiquitinates ACSL3 and facilitates its proteasomal degradation. This ubiquitin-mediated pathway acted synergistically with autophagy to control ACSL3 stability. Pharmacological inhibition of autophagy with curcumin derivative 5g (CUR5g) restored ACSL3 protein levels and suppressed ferroptosis. In MCAO rats, CUR5g\u2014administered alone or in combination with the ferroptosis inhibitor Ferfluor-1\u2014significantly improved functional recovery and reduced brain injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Our study reveals a novel autophagy\u2013NBR1\/TRIM33\u2013ACSL3 regulatory axis that drives ferroptosis in CIRI, highlighting a promising therapeutic strategy for ischemic stroke through cotargeting autophagy and ferroptosis.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      45, 676\u2013692.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15230864261470736","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:54:17Z","timestamp":1786326857000},"page":"676-692","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual Regulation of ACSL3 by TRIM33-Mediated Ubiquitination and NBR1-Dependent Autophagy: A Therapeutic Target for Cerebral Ischemia-Reperfusion Injury"],"prefix":"10.1177","volume":"45","author":[{"given":"Yueqing","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Harbin Medical University, Harbin, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Feng","sequence":"additional","affiliation":[{"name":"The electromyography (EMG) room of the Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxin","family":"Gong","sequence":"additional","affiliation":[{"name":"Biosafety Department, School of Basic Medical Sciences, Army Medical University, Chongqing, China."},{"name":"Laboratory Department, The 962nd Hospital of the PLA Joint Logistic Support Force, Harbin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8015-3789","authenticated-orcid":false,"given":"Qingqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.02.012"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01217-9"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2024.2319901"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2025.2472586"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.03.001"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.09.011"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-07237-w"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.09.027"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114671"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02274-1"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2259215"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-1039"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40170-022-00290-z"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49298-7"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092197"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.06.005"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201765R"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155595"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154111"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/M22-2453"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241307098"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00757-5"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2141534"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202208092"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph11040114"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0372-x"},{"key":"e_1_3_5_28_1","first-page":"1","article-title":"Proteostasis imbalance: Unraveling protein aggregation in neurodegenerative diseases and emerging therapeutic strategies","volume":"146","author":"Selvaraj C","year":"2025","unstructured":"Selvaraj C, , Vijayalakshmi P, , Desai D, et al. Proteostasis imbalance: Unraveling protein aggregation in neurodegenerative diseases and emerging therapeutic strategies. Adv Protein Chem Struct Biol 2025;146:1\u201334.","journal-title":"Adv Protein Chem Struct Biol"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.1871"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-02037-9"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.665331"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03830-9"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.041"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154845"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202502195"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-021-00889-7"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115724"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01688-x"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-025-01887-3"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.123967"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.85390"}],"container-title":["Antioxidants &amp; Redox Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15230864261470736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15230864261470736","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15230864261470736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:58:58Z","timestamp":1790564338000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15230864261470736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,9]]},"references-count":40,"journal-issue":{"issue":"13-15","published-print":{"date-parts":[[2026,11,1]]}},"alternative-id":["10.1177\/15230864261470736"],"URL":"https:\/\/doi.org\/10.1177\/15230864261470736","relation":{},"ISSN":["1523-0864","1557-7716"],"issn-type":[{"value":"1523-0864","type":"print"},{"value":"1557-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,9]]}}}