{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:44:52Z","timestamp":1791801892455,"version":"4.3.4"},"reference-count":63,"publisher":"SAGE Publications","issue":"16-18","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Natural Science Foundation of China","award":["12132006"],"award-info":[{"award-number":["12132006"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China","award":["22167008, 22467007"],"award-info":[{"award-number":["22167008, 22467007"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Guizhou Province","award":["ZK[2023]295"],"award-info":[{"award-number":["ZK[2023]295"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      Selenium-binding protein 1 (SELENBP1) correlates positively with the prognosis of patients with colitis and colon cancer. SELENBP1-deficient dendritic cells (DCs) promote regulatory T cell differentiation and exert direct immunomodulatory functions. This study aimed to investigate whether SELENBP1-deficient DCs mediate antitumor immune function by affecting CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell activation or exhaustion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Our findings revealed that SELENBP1 deficiency in mice accelerates colon cancer progression, characterized by reduced numbers of activated DCs and cytotoxic CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells, increased intratumoral exhaustion-related factors, and impaired CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell tumor-killing capacity. Adoptive-transfer experiments showed that SELENBP1 deficiency impairs DC antitumor activity, which may be associated with decreased intratumoral DCs, reduced cytotoxic CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells, and increased dysfunctional T cell phenotypes. Moreover,\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      cell experiments showed that the phosphatidylinositol 3-kinase\/protein kinase B and hypoxia-inducible factor-1-alpha pathways are involved in DC migration as well as DC-mediated phenotypic dysfunction of CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells. In addition,\n                      <jats:italic toggle=\"yes\">SELENBP1<\/jats:italic>\n                      expression in conventional DCs correlated positively with cytotoxic CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>This study is the first to investigate the antitumor immune function of SELENBP1 in DCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      experiments showed that SELENBP1 deficiency impairs DC migration and maturation, resulting in decreased cytotoxic CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells and increased dysfunctional T cell phenotypes. This phenomenon may underlie the accelerated colon tumor progression observed upon global SELENBP1 ablation or adoptive transfer of SELENBP1-deficient DCs. In brief, SELENBP1 deficiency impairs DC-mediated antitumor immune function.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      45, 739\u2013756.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15230864261476887","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T02:04:21Z","timestamp":1785981861000},"page":"739-756","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Selenium-Binding Protein 1 Deficiency Inhibits the Antitumor Immunity of Dendritic Cells"],"prefix":"10.1177","volume":"45","author":[{"given":"Shuang","family":"Han","sequence":"first","affiliation":[{"name":"School of Biology and Engineering (School of Modern Industry for Health and Medicine), Engineering Research Center for Bio-Perception Materials of Guizhou Province, Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Cellular Immunotherapy Engineering Research Center of Guizhou Province, Guizhou Medical University, Guiyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biology and Engineering (School of Modern Industry for Health and Medicine), Engineering Research Center for Bio-Perception Materials of Guizhou Province, Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Cellular Immunotherapy Engineering Research Center of Guizhou Province, Guizhou Medical University, Guiyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Biology and Engineering (School of Modern Industry for Health and Medicine), Engineering Research Center for Bio-Perception Materials of Guizhou Province, Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Cellular Immunotherapy Engineering Research Center of Guizhou Province, Guizhou Medical University, Guiyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Dai","sequence":"additional","affiliation":[{"name":"School of Biology and Engineering (School of Modern Industry for Health and Medicine), Engineering Research Center for Bio-Perception Materials of Guizhou Province, Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Cellular Immunotherapy Engineering Research Center of Guizhou Province, Guizhou Medical University, Guiyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Biology and Engineering (School of Modern Industry for Health and Medicine), Engineering Research Center for Bio-Perception Materials of Guizhou Province, Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Cellular Immunotherapy Engineering Research Center of Guizhou Province, Guizhou Medical University, Guiyang, China."},{"name":"Immune Cells and Antibody Engineering Research Center of Guizhou Province, Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4563-917X","authenticated-orcid":false,"given":"Yi","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Biology and Engineering (School of Modern Industry for Health and Medicine), Engineering Research Center for Bio-Perception Materials of Guizhou Province, Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Cellular Immunotherapy Engineering Research Center of Guizhou Province, Guizhou Medical University, Guiyang, China."},{"name":"Immune Cells and Antibody Engineering Research Center of Guizhou Province, Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 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