{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:57:51Z","timestamp":1790607471875,"version":"4.1.0"},"reference-count":152,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Hunan Cancer Hospital-Hunan Normal University Joint Research Grant","award":["2025004"],"award-info":[{"award-number":["2025004"]}],"id":[{"id":"https:\/\/ror.org\/053w1zy07","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Health Research Project of Hunan Provincial Health Commission","award":["20257005"],"award-info":[{"award-number":["20257005"]}]},{"name":"Hunan province college students research learning and innovative experiment project","award":["S202510542380"],"award-info":[{"award-number":["S202510542380"]}]},{"name":"Hunan Normal University Hunan Cancer Hospital Joint Research Project","award":["HNUCRI2025002"],"award-info":[{"award-number":["HNUCRI2025002"]}],"id":[{"id":"https:\/\/ror.org\/025020z88","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Hunan Normal University Hunan Cancer Hospital Joint Research Project","award":["HNUCRI2025004"],"award-info":[{"award-number":["HNUCRI2025004"]}],"id":[{"id":"https:\/\/ror.org\/025020z88","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Hunan Normal University Hunan Cancer Hospital Joint Research Project","award":["HNUCRI2025005"],"award-info":[{"award-number":["HNUCRI2025005"]}],"id":[{"id":"https:\/\/ror.org\/025020z88","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Research Grant of Regional Collaboration Center for Schistosomiasis Control Technology in Lake Regions","award":["25CSY056"],"award-info":[{"award-number":["25CSY056"]}]},{"name":"Foreign Expert Project of the Hunan Provincial Science and Technology Innovation","award":["2026RC9026"],"award-info":[{"award-number":["2026RC9026"]}]},{"name":"National Natural Science Foundation of China","award":["82100490"],"award-info":[{"award-number":["82100490"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China","award":["82372671"],"award-info":[{"award-number":["82372671"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Hunan Provincial Science and Technology Department","award":["2023ZJ1120"],"award-info":[{"award-number":["2023ZJ1120"]}],"id":[{"id":"https:\/\/ror.org\/04qgr7x96","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Large Instrument Open Fund Sponsored Project of Hunan Normal University","award":["24CSY207"],"award-info":[{"award-number":["24CSY207"]}],"id":[{"id":"https:\/\/ror.org\/053w1zy07","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants &amp; Redox Signaling"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Altered metabolism contributes to disease progression and variable treatment response, but metabolite abundance alone rarely determines whether stressed cells recover or undergo regulated cell death (RCD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Scope of Review:<\/jats:title>\n                    <jats:p>This review proposes mitochondrial quality control (MQC) as an intermediate gating layer that links metabolic signals to cell-fate execution through coordinated redox control, mitochondrial integrity, organelle turnover, and renewal. Four representative metabolites\u2014\u03b2-hydroxybutyrate (\u03b2-BHB), lactate, succinate, and acetate\u2014span complementary substrate-, receptor-, redox-, and acylation-dependent mechanisms and illustrate how distinct metabolic inputs converge on different MQC nodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Major Conclusions:<\/jats:title>\n                    <jats:p>This framework explains why the same metabolite may support adaptation in one tissue or exposure window yet lower the death threshold in another. It predicts that tissue-specific flux and functional MQC reserve will outperform bulk metabolite abundance in forecasting RCD responses, that disrupting and rescuing the dominant MQC node will, respectively, abolish and restore a metabolite-dependent death phenotype, and that MQC changes will precede modality-specific execution events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Translational Outlook:<\/jats:title>\n                    <jats:p>\n                      Clinically, this predominantly preclinical framework can now be tested through mechanism-enriched trials that integrate metabolite exposure, metabolic competence, mitochondrial target engagement, and RCD output, providing a practical route for causal validation in humans.\n                      <jats:italic toggle=\"yes\">Antioxid. Redox Signal.<\/jats:italic>\n                      00, 000\u2013000.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15230864261490413","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:03:16Z","timestamp":1790388196000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolite Regulation of Mitochondrial Quality Control and Regulated Cell Death"],"prefix":"10.1177","author":[{"given":"Jingjiang","family":"Hu","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Hunan Normal University Health Science Center, Hunan Normal University, Changsha, Hunan, China."},{"name":"Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha, Hunan, China."},{"name":"Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Changsha, Hunan, China."},{"name":"Manufacture-Based Learning and Research Demonstration Center for Human Reproductive Health New Technology of Hunan Normal University, Changsha, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenbei","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Hunan Normal University Health Science Center, Hunan Normal University, Changsha, Hunan, China."},{"name":"Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha, Hunan, China."},{"name":"Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Changsha, Hunan, China."},{"name":"Manufacture-Based Learning and Research Demonstration Center for Human Reproductive Health New Technology of Hunan Normal University, Changsha, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Hunan Normal University Health Science Center, Hunan Normal University, Changsha, Hunan, China."},{"name":"Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha, Hunan, China."},{"name":"Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Changsha, Hunan, China."},{"name":"Manufacture-Based Learning and Research Demonstration Center for Human Reproductive Health New Technology of Hunan Normal University, Changsha, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihua","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Hunan Normal University Health Science Center, Hunan Normal University, Changsha, Hunan, China."},{"name":"Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha, Hunan, China."},{"name":"Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Changsha, Hunan, China."},{"name":"Manufacture-Based Learning and Research Demonstration Center for Human Reproductive Health New Technology of Hunan Normal University, Changsha, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Ouyang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Hunan Normal University Health Science Center, Hunan Normal University, Changsha, Hunan, China."},{"name":"Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha, Hunan, China."},{"name":"Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Changsha, Hunan, China."},{"name":"Manufacture-Based Learning and Research Demonstration Center for Human Reproductive Health New Technology of Hunan Normal University, Changsha, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiqing","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Hunan Normal University Health Science Center, Hunan Normal University, Changsha, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Hunan Normal University Health Science Center, Hunan Normal University, Changsha, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Hunan Normal University Health Science Center, Hunan Normal University, Changsha, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Fan","sequence":"additional","affiliation":[{"name":"The Second People\u2019s Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongguang","family":"Tao","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Hunan Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cong","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Hunan Normal University Health Science Center, Hunan Normal University, Changsha, Hunan, China."},{"name":"Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha, Hunan, China."},{"name":"Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Changsha, Hunan, China."},{"name":"Manufacture-Based Learning and Research Demonstration Center for Human Reproductive Health New Technology of Hunan Normal University, Changsha, Hunan, China."},{"name":"Hunan Normal University Cancer Research Institute, Hunan Cancer Hospital, Hunan Normal University Health Science Center, Changsha, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Hunan Normal University Health Science Center, Hunan Normal University, Changsha, Hunan, China."},{"name":"Key Laboratory of 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