{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:31:28Z","timestamp":1787502688284,"version":"build-2736575974"},"reference-count":99,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trauma, Violence, &amp; Abuse"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>This review aims to systematically assess the current literature about prenatal epigenetic markers that lead to post-traumatic stress disorder susceptibility across the lifespan. Studies included in this review met several research criteria: Studies included (1) participants with a PTSD diagnosis according to the DSM-5, (2) prenatal epigenetic marker data that could be analyzed, and (3) explicit references to postnatal PTSD susceptibility. Our study sample fit within a timeframe of 2002 (the earliest recorded studies of prenatal susceptibility to post-traumatic stress disorder in the databases used) and February 2021 when the literature search for this review was terminated. Studies for this review were collated from PubMed, MEDLINE, Science Direct, and Boston College School of Social Work Library databases. A systematic search was conducted in these databases using basic keyword terms, such as \u201cPSTD resilience\u201d and \u201cPTSD vulnerability,\u201d and then adding clarifying terms to refine specific searches, such as \u201cepigenetics,\u201d \u201cgenetics,\u201d \u201cepigenetic markers,\u201d \u201chaplotypes,\u201d and \u201cmRNA methylation.\u201d Based on these criteria and research methods, 33 studies remained for inclusion in the review sample. This review suggests that BDNF Val66-Met, a polymorphism of FKBP5, and an altered messenger ribonucleic acid methylation marker in NR3C1 present most often in cases of PTSD. These epigenetic markers might be implicated in central neurological processes related to post-traumatic stress disorder symptomatology.<\/jats:p>","DOI":"10.1177\/15248380221109792","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T20:17:21Z","timestamp":1655497041000},"page":"2648-2660","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Stress and Susceptibility: A Systematic Review of Prenatal Epigenetic Risks for Developing Post-Traumatic Stress Disorder"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9753-6391","authenticated-orcid":false,"given":"Zachary P.","family":"Pierce","sequence":"first","affiliation":[{"name":"School of Social Work, Boston College, Chestnut Hill, MA, USA"},{"name":"The Cell to Society Laboratory, School of Social Work, Boston College, Chestnut Hill, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3539-679X","authenticated-orcid":false,"given":"Jessica M.","family":"Black","sequence":"additional","affiliation":[{"name":"School of Social Work, Boston College, Chestnut Hill, MA, USA"},{"name":"The Cell to Society Laboratory, School of Social Work, Boston College, Chestnut Hill, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"bibr1-15248380221109792","doi-asserted-by":"publisher","DOI":"10.2217\/epi.11.22"},{"key":"bibr2-15248380221109792","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.88"},{"issue":"1","key":"bibr3-15248380221109792","first-page":"1","volume":"2017","author":"Angelini F.","year":"2017","journal-title":"Hindawi, n.a"},{"key":"bibr4-15248380221109792","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.11.1291"},{"key":"bibr5-15248380221109792","doi-asserted-by":"publisher","DOI":"10.3390\/genes10020140"},{"issue":"1","key":"bibr6-15248380221109792","first-page":"1","volume":"2016","author":"Bruenig D.","year":"2016","journal-title":"Hindawi, n.a"},{"key":"bibr7-15248380221109792","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-9040-y"},{"key":"bibr8-15248380221109792","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579414001357"},{"issue":"1","key":"bibr9-15248380221109792","first-page":"1","volume":"5","author":"Chen S. 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