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In 2014, a Hispanic-serving higher education institution partnered with two community-based organizations to implement integrated substance use interventions and HIV and HCV prevention among young adults on campus and in surrounding communities. Among the 95 young adults, aged 18\u201324 years, who responded to a needs assessment survey, 91.5% were Hispanic, 53.7% were female, and 27.4% were sexual or gender minorities (SGMs) as defined by behavior and identity. SGMs had significantly higher rates of current smoking, drinking when bored, and of being told they had a drinking problem. Compared with the other young adult survey respondents, SGMs had lower health risk perceptions for tobacco, alcohol, and marijuana use and reported similar or higher rates of lifetime drug use during sex and higher rates of HIV risk behaviors. Study findings have implications for including measures for sexual orientation and gender identity in substance use studies, examining regional and cultural norms that may intersect to shape substance use among SGMs, and incorporating unique risk contexts for SGMs in interventions for substance use.<\/jats:p>","DOI":"10.1177\/1524839920933257","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T04:47:18Z","timestamp":1592196438000},"page":"559-573","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Differences in Substance Use and Sexual Risk by Sexual Orientation and Gender Identity Among University and Community Young Adults in a U.S.-Mexico Border City"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7384-0399","authenticated-orcid":false,"given":"Oralia","family":"Loza","sequence":"first","affiliation":[{"name":"The University of Texas at El Paso, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thenral","family":"Mangadu","sequence":"additional","affiliation":[{"name":"The University of Texas at El Paso, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o B.","family":"Ferreira-Pinto","sequence":"additional","affiliation":[{"name":"The University of Texas at El Paso, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Guevara","sequence":"additional","affiliation":[{"name":"The University of Texas at El Paso, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"bibr1-1524839920933257","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2017.1310219"},{"key":"bibr2-1524839920933257","doi-asserted-by":"publisher","DOI":"10.1080\/10550887.2010.509273"},{"key":"bibr3-1524839920933257","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(03)00025-4"},{"key":"bibr4-1524839920933257","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214906"},{"key":"bibr5-1524839920933257","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2012.00269.x"},{"key":"bibr6-1524839920933257","unstructured":"Centers for Disease Control and Prevention. 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