{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:11:23Z","timestamp":1777943483114,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of complex endovascular treatment for limb salvage in patients with critical limb ischemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a prospective study, 23 patients (13 men; mean age 70 \u00b1 11 years, range 44\u201387) with ischemic ulceration or gangrene of 25 lower limbs were enrolled at 4 sites to evaluate treatment with excimer laser recanalization followed by balloon angioplasty with optional stenting in the superficial femoral, popliteal, and\/or tibial arteries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Multiple lesions (mean 3.1, range 1\u20138) were treated in most cases. Reduction of stenosis\/occlusion to &lt;50% was achieved in 22 (88%) limbs. Individual cases of vessel perforation, inability to cross the lesion, and excessive residual stenosis accounted for the 3 failures. Over a 6-month period, 4 patients died of cardiac comorbidity and 1 was lost to follow-up. Adverse events included 4 minor and 2 below-knee amputations, 4 secondary angioplasties, and 4 femorodistal bypasses. The mean wound area reduction was 70% at 3 months, increasing to 89% at 6 months. According to life table analysis, the limb salvage rate was 90% with bypass and 69% without in the successfully treated patients (corresponding intention-to-treat rates were 79% and 61%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Complex endovascular treatment combining laser debulking and angioplasty\/stenting offers an alternative for patients with critical limb ischemia who lack good surgical options.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/152660280200900509","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T06:51:23Z","timestamp":1426747883000},"page":"599-604","source":"Crossref","is-referenced-by-count":35,"title":["Complex Endovascular Treatment for Critical Limb Ischemia in Poor Surgical Candidates: A Pilot Study"],"prefix":"10.1177","volume":"9","author":[{"given":"Bruce 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