{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:54:56Z","timestamp":1778619296956,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report the 1-year angiographic and clinical outcome from a prospective single-center study investigating the infrapopliteal application of sirolimus-eluting versus bare metal stents in patients with critical limb ischemia (CLI) who underwent below-the-knee endovascular revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Stenting was performed as a bailout procedure for suboptimal angioplasty results (flow-limiting dissection, elastic recoil, or postangioplasty residual stenosis &gt;30%). In the first 29 patients, infrapopliteal stenting was performed with bare metal stents (group B) and with sirolimus-eluting stents in the other 29 patients (group S).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Below-the-knee angioplasty and stenting involved 65 lesions in 40 infrapopliteal arteries of 29 limbs in group B and 66 lesions in 41 infrapopliteal arteries of 29 limbs in group S. Baseline comorbidities (hyperlipidemia and symptomatic cardiac and carotid disease) were more pronounced in group S (p&lt;0.05). At 6 months, sirolimus-eluting stents demonstrated significantly higher primary patency (OR 5.625, 95% CI 1.711 to 18.493, p=0.004) and decreased in-stent binary restenosis (OR 0.067, 95% CI 0.021 to 0.017, p&lt;0.001) and in-segment binary restenosis (OR 0.229, 95% CI 0.099 to 0.533, p=0.001). After 1 year, sirolimus-eluting stents were steadily associated with increased primary patency (OR 10.401, 95% CI 3.425 to 31.589, p&lt;0.001) and significantly less in-stent (OR 0.156, 95% CI 0.060 to 0.407, p&lt;0.001) and in-segment (OR 0.089, 95% CI 0.023 to 0.349, p=0.001) binary restenosis. In addition, sirolimus-eluting stents were associated with significantly fewer cumulative target lesion reinterventions at 6 months (OR 0.057, 95% CI 0.008 to 0.426, p=0.005) and 1 year (OR 0.238, 95% CI 0.067 to 0.841, p=0.026). No significant differences between groups B and S were noted at 1 year with respect to mortality (10.3% versus 13.8%, respectively), minor amputation (17.2% versus 10.3%), or limb salvage (100% versus 96%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The application of sirolimus-eluting stents reduces the restenosis rate in the infrapopliteal arteries and the rate of repeat endovascular procedures the first year after treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/152660280701400217","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T10:23:04Z","timestamp":1426846984000},"page":"241-250","source":"Crossref","is-referenced-by-count":54,"title":["Sirolimus-Eluting versus Bare Stents after Suboptimal Infrapopliteal Angioplasty for Critical Limb Ischemia: Enduring 1-Year Angiographic and Clinical Benefit"],"prefix":"10.1177","volume":"14","author":[{"given":"Dimitris","family":"Siablis","sequence":"first","affiliation":[{"name":"Department of Radiology (Angiography Suite), University Hospital of Patras, Rion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris","family":"Karnabatidis","sequence":"additional","affiliation":[{"name":"Department of Radiology (Angiography Suite), University Hospital of Patras, Rion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Katsanos","sequence":"additional","affiliation":[{"name":"Department of Radiology (Angiography Suite), University Hospital of Patras, Rion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George C.","family":"Kagadis","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, University of Patras, Rion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pantelis","family":"Kraniotis","sequence":"additional","affiliation":[{"name":"Department of Radiology (Angiography Suite), University Hospital of Patras, Rion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanassios","family":"Diamantopoulos","sequence":"additional","affiliation":[{"name":"Department of Radiology (Angiography Suite), University Hospital of Patras, Rion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Tsolakis","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital of Patras, Rion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,4,1]]},"reference":[{"issue":"1","key":"bibr1-152660280701400217","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0741-5214(00)81002-2","volume":"31","author":"Dormandy 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