{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:16:03Z","timestamp":1788200163871,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the safety and performance of ultrasound-enhanced thrombolysis in the treatment of acute thrombotic or embolic occlusion of the lower limb arteries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>From April 2005 to July 2006, 25 patients (15 men; mean age 64.1 years, range 37\u201382) presenting with acute (&lt;14 days old) occlusions of the lower limb arteries were treated with local thrombolysis [recombinant tissue plasminogen activator (rtPA)] in a dosage of 1.0 mg\/h using the EKOS Lysus Peripheral Catheter System with an ultrasound core. No bolus injection of rtPA was given. The mean occlusion length was 25.1 cm (range 2\u201370).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The technical success rate was 100%. Total clot removal was achieved in 22 (88%) patients after 16.9 hours (range 5\u201324) using a mean 17 mg (range 5\u201325) of rtPA. In 8 cases, total clot removal of the main lesion was achieved after 6 hours (6 mg of rtPA). In 1 patient, lysis was stopped after 2.5 hours because of bleeding due a dislocation of the introducer sheath. In 2 cases, total clot removal could not be achieved; these patients were successfully treated with thromboaspiration. At the 1-month follow-up, the treated vessel was still patent in 20 patients. Two reocclusions occurred; 1 was treated with a bypass graft and the other with conservative therapy. There were no cases of amputation or death during follow-up. There were no side effects related to rtPA or the catheter system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study demonstrates that local lysis of acute arterial occlusions using the Lysus Peripheral Catheter System is safe and effective. Blood flow is restored quickly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/152660280701400402","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T10:24:38Z","timestamp":1426847078000},"page":"438-443","source":"Crossref","is-referenced-by-count":41,"title":["Treatment of Critical Limb Ischemia Using Ultrasound-Enhanced Thrombolysis (PARES Trial): Final Results"],"prefix":"10.1177","volume":"14","author":[{"given":"Christian","family":"Wissgott","sequence":"first","affiliation":[{"name":"Department of Radiology, DRK Kliniken Mark Brandenburg, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Radiology, DRK Kliniken Mark Brandenburg, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kamusella","sequence":"additional","affiliation":[{"name":"Department of Radiology, DRK Kliniken Mark Brandenburg, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann J.","family":"Steinkamp","sequence":"additional","affiliation":[{"name":"Department of Radiology, DRK Kliniken Mark Brandenburg, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,8,1]]},"reference":[{"key":"bibr1-152660280701400402","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0733-8627(20)30736-7","volume":"10","author":"Lavanier GL","year":"1992","journal-title":"Emerg Med Clin 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