{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:15:13Z","timestamp":1790810113807,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Purpose: To present the results of rheolytic pharmacomechanical thrombectomy (PMT) for the management of acute limb ischemia (ALI) as reported in the PEARL Registry ( PEripheral Use of AngioJet Rheolytic Thrombectomy with a variety of catheter Lengths). Methods: A total of 283 patients (mean age 65\u00b113 years; 170 men) presenting with ALI undergoing treatment with the AngioJet System at participating institutions were enrolled in the registry. Rutherford ALI categories included 26% with viable limbs, 38% with marginally threatened limbs, 35% with immediately threatened limbs, and &lt;1% with irreversible damage. Procedure and follow-up data were collected for the calculation of outcomes. To control for patient selection bias, propensity score matching was used to compare outcomes for patients undergoing PMT with or without catheter-directed thrombolysis (CDT). Results: Procedure success was achieved in 235 (83%) of 283 patients. Half of the procedures (147, 52%) were completed without the need for adjunctive CDT. At 12-month follow-up, amputation-free survival and freedom from mortality were 81% and 91%, respectively; 12-month freedom from bleeding requiring transfusion was 91%, and freedom from renal failure was 95%. Subgroup analysis revealed significantly better outcomes in patients without infrapopliteal involvement and those who underwent PMT without CDT. In the matched cohorts, higher rates of procedure success, 12-month amputation-free survival, and 12-month freedom from amputation were observed in the PMT without CDT group (88% vs 74%, p=0.021; 87% vs 72%, p=0.028; 96% vs 81%, p=0.01, respectively). Conclusions: The results support the use of PMT as a first-line treatment for ALI, providing a rapid reperfusion to the extremity, reduced procedure time, and an acceptable risk profile without compromising limb salvage.<\/jats:p>","DOI":"10.1177\/1526602815592849","type":"journal-article","created":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T11:13:37Z","timestamp":1437131617000},"page":"546-557","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":108,"title":["Rheolytic Pharmacomechanical Thrombectomy for the Management of Acute Limb Ischemia"],"prefix":"10.1177","volume":"22","author":[{"given":"Daniel A.","family":"Leung","sequence":"first","affiliation":[{"name":"Christiana Care Health Services, Newark, DE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence R.","family":"Blitz","sequence":"additional","affiliation":[{"name":"Chilton Memorial Hospital, Pompton Plains, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Nelson","sequence":"additional","affiliation":[{"name":"Technomics Research, LLC, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Amin","sequence":"additional","affiliation":[{"name":"Reading Hospital & Medical Center, West Reading, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Soukas","sequence":"additional","affiliation":[{"name":"Miriam Hospital, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravinda","family":"Nanjundappa","sequence":"additional","affiliation":[{"name":"Charleston Area Medical Center, Charleston, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Christiana Care Health Services, Newark, DE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lookstein","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene J.","family":"Simoni","sequence":"additional","affiliation":[{"name":"Pennsylvania State University and the Milton S. Hershey Medical Center, Hershey, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,6,24]]},"reference":[{"key":"bibr1-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2012.09.026"},{"key":"bibr2-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1006054"},{"key":"bibr3-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.03.244"},{"key":"bibr4-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2010.02.009"},{"key":"bibr5-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.04.036"},{"key":"bibr6-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199409000-00003"},{"key":"bibr7-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804163381603"},{"key":"bibr8-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(94)70214-4"},{"key":"bibr9-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.09.024"},{"key":"bibr10-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.07.086"},{"key":"bibr11-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.08.045"},{"key":"bibr12-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.10.054"},{"key":"bibr13-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.08.064"},{"key":"bibr14-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1177\/152660280200900402"},{"key":"bibr15-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(97)70045-4"},{"key":"bibr16-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.211.1.r99ap4739"},{"key":"bibr17-1526602815592849","volume-title":"Propensity Score Analysis: Statistical Methods and Applications","author":"Guo S","year":"2010"},{"key":"bibr18-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1080\/00031305.1985.10479383"},{"key":"bibr19-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1989.10478874"},{"key":"bibr20-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20216"},{"key":"bibr21-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(96)70067-8"},{"key":"bibr22-1526602815592849","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.06.109"}],"container-title":["Journal of Endovascular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1526602815592849","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1526602815592849","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1526602815592849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:29:23Z","timestamp":1777498163000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1526602815592849"}},"subtitle":["Results From the PEARL Registry"],"short-title":[],"issued":{"date-parts":[[2015,6,24]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1177\/1526602815592849"],"URL":"https:\/\/doi.org\/10.1177\/1526602815592849","relation":{},"ISSN":["1526-6028","1545-1550"],"issn-type":[{"value":"1526-6028","type":"print"},{"value":"1545-1550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,24]]}}}