{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:20:57Z","timestamp":1778905257978,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Purpose: To investigate the impact on restenosis rates of deep injury to the adventitial layer during directional atherectomy. Methods: Between 2007 and 2010, 116 consecutive patients (mean age 69.6 years; 56 men) with symptomatic femoropopliteal stenoses were treated with directional atherectomy at a single center. All patients had claudication and TASC A\/B lesions in the superficial femoral or popliteal arteries. Histopathology analysis of atherectomy specimens was performed to identify adventitial injury. Clinical follow-up included physical examination and duplex ultrasound scans at 3, 6, and 12 months in all patients. The primary endpoint was the duplex-documented 1-year rate of restenosis, which was determined by a peak systolic velocity ratio &lt;2.4. Patients were dichotomized by the presence or absence of adventitial or medial cuts as evaluated by histopathology. Results: Adventitial injury were identified in 62 (53%) of patients. There were no differences in baseline demographic and clinical features (p&gt;0.05), lesion length (58.7\u00b112.8 vs 56.2\u00b113.6 mm, p=0.40), or vessel runoff (1.9\u00b10.6 vs 2.0\u00b10.6, p=0.37) between patients with and without adventitial injury, respectively. The overall 1-year incidence of restenosis was 57%, but the rate was significantly higher (p&lt;0.0001) in patients with adventitial or medial injury (97%, 60\/62) as compared with those without (11%, 6\/54). Conclusion: Lack of adventitial injury after atherectomy for femoropopliteal stenosis is strongly related to patency at 1 year.<\/jats:p>","DOI":"10.1177\/1526602815597683","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T15:34:11Z","timestamp":1442849651000},"page":"712-715","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":47,"title":["Histopathological Evidence of Adventitial or Medial Injury Is a Strong Predictor of Restenosis During Directional Atherectomy for Peripheral Artery Disease"],"prefix":"10.1177","volume":"22","author":[{"given":"Arthur","family":"Tarricone","sequence":"first","affiliation":[{"name":"Mount Sinai Heart, Mount Sinai Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziad","family":"Ali","sequence":"additional","affiliation":[{"name":"Center for Interventional Vascular Therapy, Division of Cardiology, New York Presbyterian Hospital and Columbia University, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anitha","family":"Rajamanickam","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Mount Sinai Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Gujja","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Mount Sinai Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal","family":"Kapur","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Mount Sinai Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K-Raman","family":"Purushothaman","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Mount Sinai Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meerarani","family":"Purushothaman","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Mount Sinai Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Mount Sinai Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Zalewski","sequence":"additional","affiliation":[{"name":"Center for Interventional Vascular Therapy, Division of Cardiology, New York Presbyterian Hospital and Columbia University, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micheal","family":"Parides","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Mount Sinai Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Overbey","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Mount Sinai Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Wiley","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Mount Sinai Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Mount Sinai Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"bibr1-1526602815597683","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.jacc.2013.01.004","volume":"61","author":"Rooke TW","year":"2013","journal-title":"J Am Coll 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