{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T14:50:54Z","timestamp":1777819854374,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Purpose: To compare primary placement of a self-expanding nitinol stent to percutaneous transluminal angioplasty (PTA) with bailout stenting in infrapopliteal arteries of patients with severe intermittent claudication or critical limb ischemia (CLI). Methods: In the EXPAND trial ( ClinicalTrials.gov; identifier NCT00906022), 92 patients (mean age 72.9\u00b19.5 years; 62 men) undergoing treatment for infrapopliteal stenosis in 11 European centers were randomized 1:1 to either self-expanding nitinol stenting with the Astron Pulsar\/Pulsar-18 nitinol stent or PTA with bailout stenting. The primary endpoint was sustainable clinical improvement after 12 months, defined as a \u22651-category increase for Rutherford category 3 patients or a \u22652-category increase for CLI patients (Rutherford categories 4\/5) compared with baseline. Furthermore, target lesion revascularization (TLR), mortality, and amputation were assessed after 12 months. Results: Sustained clinical improvement at 1 year was observed in 74.3% of the patients treated with primary stenting and in 68.6% of the patients treated with PTA and bailout stenting (p&gt;0.05). Kaplan-Meier estimates of freedom from TLR (76.6% and 77.6%), mortality (7.4% vs 2.1%), and amputation [8.9% (major 6.7%) vs 13.2% (major 8.7%)] at 1 year were not significantly different. Conclusion: Primary self-expanding nitinol stenting did not show statistically different clinical outcomes compared to angioplasty with bailout stenting for infrapopliteal lesions.<\/jats:p>","DOI":"10.1177\/1526602815598955","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T15:34:11Z","timestamp":1442849651000},"page":"690-697","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Primary Self-EXPANDing Nitinol Stenting vs Balloon Angioplasty With Optional Bailout Stenting for the Treatment of Infrapopliteal Artery Disease in Patients With Severe Intermittent Claudication or Critical Limb Ischemia (EXPAND Study)"],"prefix":"10.1177","volume":"22","author":[{"given":"Karl-Ludwig","family":"Schulte","sequence":"first","affiliation":[{"name":"Vascular Center Berlin, SGK Behandlungszentrum, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Pilger","sequence":"additional","affiliation":[{"name":"Department of Angiology, Medical University Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Schellong","sequence":"additional","affiliation":[{"name":"Internal Medicine, Dresden-Friedrichstadt Hospital, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kong Ten","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, UHN Toronto General Hospital, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Baumann","sequence":"additional","affiliation":[{"name":"Miami Cardiac and Vascular Institute, Baptist Hospital, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Langhoff","sequence":"additional","affiliation":[{"name":"Department of Angiology, St. Gertrauden Krankenhaus, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Torsello","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University of M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Zeller","sequence":"additional","affiliation":[{"name":"Department of Angiology, Universit\u00e4ts-Herzzentrum Freiburg-Bad Krozingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Amendt","sequence":"additional","affiliation":[{"name":"Internal Medicine, Diakonissenkrankenhaus Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Brodmann","sequence":"additional","affiliation":[{"name":"Department of Angiology, Medical University Graz, 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