{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T14:51:04Z","timestamp":1777819864596,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T00:00:00Z","timestamp":1439856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Purpose: To compare the objective performance goals (OPGs) and patient-centered outcomes of isolated tibial interventions in patients with tissue loss who were on hemodialysis (HD) to patients with tissue loss who were not on HD. Methods: Interrogation of a prospectively maintained database identified 242 critical limb ischemia (CLI) patients who underwent isolated tibial interventions for tissue loss in a single limb between 2007 and 2012. The 78 patients (mean age 66\u00b112 years; 44 men) on HD were compared with 164 patients (mean age 50\u00b113 years; 82 men) who were not on HD. There was an equal distribution of the tibial vessels treated; 152 (63%) patients had more than one treated tibial vessel. Patient-centered outcomes of clinical efficacy (absence of recurrent symptoms, maintenance of ambulation, and no major amputation), amputation-free survival (AFS), and freedom from major adverse limb events (MALE) were evaluated. The Society for Vascular Surgery OPGs were defined at 30 days and 1 year. Results: The 30-day major adverse cardiac events was significantly higher (p=0.004) in the HD group (5, 5%) compared with the no-HD group (0%), but both remained under the stated OPG of \u226410%. The 30-day MALE rates were significantly higher than the stated \u22649% OPG at 13% and 18% for the no-HD and HD groups, respectively. At 1 year, the rates for AFS, freedom from MALE, limb salvage, and survival did not achieve the stated Society for Vascular Surgery OPGs in the HD group. Clinical efficacy was 61% and 25% at 3 years for the no-HD and HD groups, respectively (p&lt;0.01). Overall, AFS was 54% and 22% and freedom from MALE was 56% and 27% at 3 years for the no-HD and HD groups, respectively (both p&lt;0.01). Conclusion: Tibial intervention for tissue loss in patients on HD is a valid treatment option but is associated with a high MALE rate. Three-year outcomes remain relatively poor, with &lt;25% success in terms of clinical efficacy and AFS.<\/jats:p>","DOI":"10.1177\/1526602815602074","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T15:34:11Z","timestamp":1442849651000},"page":"681-689","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Outcomes of Isolated Tibial Endovascular Interventions for Tissue Loss in CLI Patients on Hemodialysis"],"prefix":"10.1177","volume":"22","author":[{"given":"Mark G.","family":"Davies","sequence":"first","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Department of Surgery, University of Texas Health Science Center at San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hosam F.","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Division of Vascular Diseases and Surgery, Wexner Medical Center, Ohio State University, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,8,18]]},"reference":[{"key":"bibr1-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.11.005"},{"key":"bibr2-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2003.11.038"},{"key":"bibr3-1526602815602074","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01070905"},{"key":"bibr4-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000061776.60146.02"},{"key":"bibr5-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.01.035"},{"key":"bibr6-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.10.109"},{"key":"bibr7-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.10.1043"},{"key":"bibr8-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000111245.75752.C6"},{"key":"bibr9-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.12.037"},{"key":"bibr10-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.04.013"},{"key":"bibr11-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.120046"},{"key":"bibr12-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.05.055"},{"key":"bibr13-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-006-0242-y"},{"key":"bibr14-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.09.044"},{"key":"bibr15-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(97)70045-4"},{"key":"bibr16-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24370"},{"key":"bibr17-1526602815602074","first-page":"734","volume":"15","author":"Silverberg D","year":"2013","journal-title":"Isr Med Assoc J"},{"key":"bibr18-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2012.12.005"},{"key":"bibr19-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70142-7"},{"key":"bibr20-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1583\/11-3782.1"},{"key":"bibr21-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.07.062"},{"key":"bibr22-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70069-8"},{"key":"bibr23-1526602815602074","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.115607"}],"container-title":["Journal of Endovascular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1526602815602074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1526602815602074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1526602815602074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:29:26Z","timestamp":1777498166000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1526602815602074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,18]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1177\/1526602815602074"],"URL":"https:\/\/doi.org\/10.1177\/1526602815602074","relation":{},"ISSN":["1526-6028","1545-1550"],"issn-type":[{"value":"1526-6028","type":"print"},{"value":"1545-1550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,18]]}}}