{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:04:04Z","timestamp":1790625844635,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"crossref","award":["20160266, 20150529, 20140722, 20140811 and 2013065"],"award-info":[{"award-number":["20160266, 20150529, 20140722, 20140811 and 2013065"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001862","name":"The Swedish Research Council","doi-asserted-by":"crossref","award":["2016-0176, and 2015-04476"],"award-info":[{"award-number":["2016-0176, and 2015-04476"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Stockholm County Council","award":["ALF project: 20150537"],"award-info":[{"award-number":["ALF project: 20150537"]}]},{"name":"The Stockholm County Council","award":["Senior Clinical Research Appointment: 20150906"],"award-info":[{"award-number":["Senior Clinical Research Appointment: 20150906"]}]},{"name":"The Stockholm County Council","award":["the Health Medicine and Technology: 20150916"],"award-info":[{"award-number":["the Health Medicine and Technology: 20150916"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n                    Purpose: To investigate how 2-dimensional geometric parameters differ between ruptured and asymptomatic abdominal aortic aneurysms (AAAs) and provide a biomechanical explanation for the findings. Methods: The computed tomography angiography (CTA) scans of 30 patients (mean age 77\u00b110 years; 23 men) with ruptured AAAs and 60 patients (mean age 76\u00b18 years; 46 men) with asymptomatic AAAs were used to measure maximum sac diameter along the center lumen line, the cross-sectional lumen area, the total vessel area, the intraluminal thrombus (ILT) area, and corresponding volumes. The CTA data were segmented to create 3-dimensional patient-specific models for finite element analysis to compute peak wall stress (PWS) and the peak wall rupture index (PWRI). To reduce confounding from the maximum diameter, 2 diameter-matched groups were selected from the initial patient cohorts: 28 ruptured AAAs and another with 15 intact AAAs (diameters 74\u00b112 vs 73\u00b111, p=0.67). A multivariate model including the maximum diameter, the lumen area, and the ILT area of the 60 intact aneurysms was employed to predict biomechanical rupture risk parameters. Results: In the diameter-matched subgroup comparison, ruptured AAAs had a significantly larger cross-sectional lumen area (1954\u00b11254 vs 1120\u00b1623 mm\n                    <jats:sup>2<\/jats:sup>\n                    , p=0.023) and lower ILT area ratio (55\u00b124 vs 68\u00b124, p=0.037). The ILT area (2836\u00b11462 vs 2385\u00b11364 mm\n                    <jats:sup>2<\/jats:sup>\n                    , p=0.282) and the total vessel area (3956\u00b11170 vs 4338\u00b11388 mm\n                    <jats:sup>2<\/jats:sup>\n                    , p=0.384) did not differ statistically between ruptured and intact aneurysms. The PWRI was increased in ruptured AAAs (0.80 vs 0.48, p&lt;0.001), but the PWS was similar (249 vs 284 kPa, p=0.194). In multivariate regression analysis, lumen area was significantly positively associated with both PWS (p&lt;0.001) and PWRI (p&lt;0.01). The ILT area was also significantly positively associated with PWS (p&lt;0.001) but only weakly with PWRI (p&lt;0.01). The lumen area conferred a higher risk increase in both PWS and PWRI when compared with the ILT area. Conclusion: The lumen area is increased in ruptured AAAs compared to diameter-matched asymptomatic AAAs. Furthermore, this finding may in part be explained by a relationship with biomechanical rupture risk parameters, in which lumen area, irrespective of maximum diameter, increases PWS and PWRI. These observations thus suggest a possible method to improve prediction of rupture risk in AAAs by measuring the lumen area without the use of computational modeling.\n                  <\/jats:p>","DOI":"10.1177\/1526602818808292","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T01:30:19Z","timestamp":1540431019000},"page":"750-756","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Aortic Lumen Area Is Increased in Ruptured Abdominal Aortic Aneurysms and Correlates to Biomechanical Rupture Risk"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-2526","authenticated-orcid":false,"given":"Antti","family":"Siika","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Lindquist Liljeqvist","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecka","family":"Hultgren","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"},{"name":"Department of Vascular Surgery, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Christian","family":"Gasser","sequence":"additional","affiliation":[{"name":"Department of Solid Mechanics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden"},{"name":"Department of Vascular Surgery, Karolinska University Hospital, Stockholm, 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