{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:14:16Z","timestamp":1787019256145,"version":"build-2736575974"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Purpose: To report the 1-year results of a multicenter study of peripheral artery disease (PAD) treatment with a variety of endovascular treatment strategies employed in routine practice. Materials and Methods: The LIBERTY trial ( ClinicalTrials.gov identifier NCT01855412) is a prospective, observational, core laboratory\u2013assessed, multicenter study of endovascular device intervention in 1204 subjects (mean age 69.8\u00b110.7 years; 770 men) stratified by Rutherford category (RC): claudicants (RC2,3; n=501) and critical limb ischemia (CLI) with no\/minimal tissue loss (RC4,5; n=603) or significant tissue loss (RC6; n=100). Key outcomes included quality of life (QoL) measures (VascuQol and EuroQol) and freedom from major adverse events (MAE), defined as death (within 30 days), major amputation, and target vessel revascularization based on Kaplan-Meier analysis. Results: Successful revascularization was beneficial, with RC improvement noted across all groups. Thirty-day freedom from MAE estimates were high across all groups: 99.2% in RC2,3, 96.1% in RC4,5, and 90.8% in RC6. At 12 months, the freedom from MAE was 82.6% in RC2,3, 73.2% in RC4,5, and 59.3% in RC6 patients. Estimates for freedom from major amputation at 12 months were 99.3%, 96.0%, and 81.7%, respectively. QoL scores improved significantly across all domains in all groups with 12-month VascuQol total scores of 5.3, 5.0, and 4.8 for RC2,3, RC4,5, and RC6, respectively. Conclusion: The results indicate that peripheral endovascular intervention is a viable treatment option for RC2,3, RC4,5, and RC6 patients as evidenced by the high freedom from major amputation, as well as the improvement in QoL and the RC at 12 months. Furthermore, primary unplanned amputation is often not necessary in RC6.<\/jats:p>","DOI":"10.1177\/1526602819827295","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T04:21:05Z","timestamp":1549426865000},"page":"143-154","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["One-Year Results of the LIBERTY 360 Study: Evaluation of Acute and Midterm Clinical Outcomes of Peripheral Endovascular Device Interventions"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6351-8080","authenticated-orcid":false,"given":"Jihad","family":"Mustapha","sequence":"first","affiliation":[{"name":"Advanced Cardiac and Vascular Amputation Prevention Centers, Grand Rapids, MI, USA"},{"name":"Michigan State University, E. Lansing, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Gray","sequence":"additional","affiliation":[{"name":"Main Line Health, Lankenau Heart Institute, Wynnewood, PA"},{"name":"Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad J.","family":"Martinsen","sequence":"additional","affiliation":[{"name":"Scientific Affairs, Cardiovascular Systems, Inc, St Paul, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan W.","family":"Bolduan","sequence":"additional","affiliation":[{"name":"Scientific Affairs, Cardiovascular Systems, Inc, St Paul, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George L.","family":"Adams","sequence":"additional","affiliation":[{"name":"North Carolina Heart and Vascular, Rex Hospital, UNC School of Medicine, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0612-4269","authenticated-orcid":false,"given":"Gary","family":"Ansel","sequence":"additional","affiliation":[{"name":"Riverside Methodist Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Jaff","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Newton-Wellesley Hospital, Newton, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"key":"bibr1-1526602819827295","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61249-0"},{"key":"bibr2-1526602819827295","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61576-7"},{"key":"bibr3-1526602819827295","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000697"},{"key":"bibr4-1526602819827295","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000471"},{"key":"bibr5-1526602819827295","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"bibr6-1526602819827295","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(97)70045-4"},{"key":"bibr7-1526602819827295","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00668.x"},{"key":"bibr8-1526602819827295","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.07.065"},{"key":"bibr9-1526602819827295","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2017.10.014"},{"key":"bibr10-1526602819827295","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105243442108"},{"key":"bibr11-1526602819827295","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.3.538"},{"key":"bibr12-1526602819827295","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1360"},{"key":"bibr13-1526602819827295","unstructured":"Mustapha J, Martinsen BJ, Igyarto Z. LIBERTY 360\u00b0 Study presentation at AMP 2016 reveals hope for Rutherford-6 CLI patients. Cath Lab Digest. 2016;24(10).\n                      http:\/\/www.cathlabdigest.com\/article\/LIBERTY-360%C2%B0-Study-Presentation-AMP-2016-Reveals-Hope-Rutherford-6-CLI-Patients\n                      . 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Treatment Strategies for Patients With Peripheral Artery Disease. Rockville, MD: Agency for Healthcare Research and Quality; 2013.\n                      http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK148574\/\n                      . 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Endovascular Today. 2017;16:106-108.\n                      http:\/\/evtoday.com\/2017\/10\/current-considerations-on-real-world-evidence-use-in-fda-regulatory-submissions\/\n                      . 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