{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:18:20Z","timestamp":1793261900565,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T00:00:00Z","timestamp":1552608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>\n                    Purpose: To assess calcium patterns in superficial femoral artery (SFA) disease before and after balloon angioplasty \u00b1 stent implantation using fluoroscopy, angiography, and intravascular ultrasound (IVUS) imaging and then correlate calcification severity and midterm clinical outcomes. Materials and Methods: A multicenter investigation was carried out to retrospectively review 130 symptomatic patients (mean age 73.2\u00b18.4 years; 86 men) with de novo SFA lesions who had successfully undergone endovascular therapy (EVT) at 7 centers between January and October 2015. The primary outcome was lumen gain measured as minimum lumen area (MLA) in post-EVT IVUS images according to calcification severity. The secondary outcomes included rates of stent malapposition, restenosis, and clinically-driven target lesion revascularization (TLR). Results: A total of 102 (78.5%) cases had calcification in the lesions over a mean length of 64.3\u00b172.8 mm. Of these, 70 cases were classified as having bilateral calcification according to fluoroscopy and angiography; 50 (49%) lesions had \u2265180\u00b0 calcification according to IVUS. The lumen gain in calcified lesions was significantly smaller than in the 28 noncalcified lesions (14.1\u00b14.4 vs 17.8\u00b15.2 mm\n                    <jats:sup>2<\/jats:sup>\n                    , p&lt;0.001). IVUS-evaluated circumferential distribution of calcium (&lt;180\u00b0 or \u2265180\u00b0) was independently associated with lumen gain after EVT (p&lt;0.001). Among the calcification characteristics, a calcification angle \u2265180\u00b0 showed the strongest correlation to postprocedure MLA. Moreover, the restenosis rate was significantly higher in the severe (\u2265180\u00b0) calcification group (p&lt;0.018). The severity of calcification was also associated with the risk of stent malapposition (p=0.022 for trend) but not TLR (p=0.57). Conclusion: IVUS evaluation of calcification in SFA lesions predicted lumen gain after EVT. Severe calcification in a \u2265180\u00b0 arc prevented successful dilation of the lesion with either plain balloon angioplasty or a nitinol stent. Accurate assessment of calcification patterns by IVUS is useful in maximizing the efficacy of endovascular therapy.\n                  <\/jats:p>","DOI":"10.1177\/1526602819836095","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T06:11:48Z","timestamp":1552630308000},"page":"322-330","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":72,"title":["Lumen Gain After Endovascular Therapy in\n                    <i>C<\/i>\n                    alcified Superficial Femoral Artery\n                    <i>O<\/i>\n                    cclusive\n                    <i>D<\/i>\n                    iseas\n                    <i>e<\/i>\n                    Assessed by Intravascular Ultrasound (CODE Study)"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7001-9220","authenticated-orcid":false,"given":"Masahiko","family":"Fujihara","sequence":"first","affiliation":[{"name":"Department of Cardiology, Kishiwada Tokushukai Hospital, Kishiwada, Japan"},{"name":"Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amane","family":"Kozuki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Nakatsu Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Tsubakimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Diabetes Care Medicine, Osaka University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5860-3021","authenticated-orcid":false,"given":"Yoshiaki","family":"Shintani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shin-Koga Hospital, Kurume, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Morinomiya Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Osaka General Medical Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Nakama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6496-7515","authenticated-orcid":false,"given":"Yoshiaki","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kishiwada Tokushukai Hospital, Kishiwada, 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