{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T22:46:19Z","timestamp":1777848379090,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Purpose: To report the outcomes of bypass grafting (BG) vs endovascular therapy (EVT) in patients with non-dialysis-dependent chronic kidney disease (CKD) and chronic limb-threatening ischemia (CLTI). Materials and Methods: The CRITISCH Registry is a prospective, national, interdisciplinary, multicenter registry evaluating the current practice of all available treatment options in 1200 consecutive CLTI patients. For the purposes of this analysis, only the 337 patients with non-dialysis-dependent CKD treated by either BG (n=86; median 78 years, 48 men) or EVT (n=251; median age 80 years, 135 men) were analyzed. The primary composite outcome was amputation-free survival (AFS); secondary outcomes were overall survival (OS) and amputation-free time (AFT). All outcomes were evaluated in Cox proportional hazards models; the results are reported as the hazard ratio (HR) and 95% confidence interval (CI). Results: The Cox regression analysis revealed a significantly greater hazard of amputation or death after BG (HR 1.78, 95% CI 1.05 to 3.03, p=0.028). The models for AFT and overall survival also suggested a higher hazard for BG, but the differences were not significant (AFT: HR 1.66, 95% CI 0.78 to 3.53, p=0.188; OS: HR 1.41, 95% CI 0.80 to 2.47, p=0.348). The absence of runoff vessels (HR 1.73, 95% CI 1.15 to 2.60, p=0.008) was associated with a decreased AFS. The likelihood of amputation was higher in male patients (HR 2.21, 95% CI 1.10 to 4.45, p=0.027) and was associated with a lack of runoff vessels (HR 1.95, 95% CI 0.96 to 3.95, p=0.065) and myocardial infarction (HR 3.74, 95% CI 1.23 to 11.35, p=0.020). Death was more likely in patients without runoff vessels (HR 1.76, 95% CI 1.11 to 2.80, p=0.016) and those with a higher risk score (HR 1.73, 95% CI 1.03 to 2.91, p=0.038). Conclusion: This analysis suggested that BG was associated with poorer AFS than EVT in patients with non-dialysis-dependent CKD and CLTI. Male sex, previous myocardial infarction, and the absence of runoff vessels were additionally identified as predictors of poorer outcomes.<\/jats:p>","DOI":"10.1177\/1526602820938465","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T06:15:02Z","timestamp":1594102502000},"page":"599-607","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Bypass Grafting vs Endovascular Therapy in Patients With Non-Dialysis-Dependent Chronic Kidney Disease and Chronic Limb-Threatening Ischemia (CRITISCH Registry)"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9775-9210","authenticated-orcid":false,"given":"Konstantinos","family":"Stavroulakis","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, St. Franziskus Hospital M\u00fcnster, Germany"},{"name":"Department of Vascular Surgery, Ludwig-Maximilians-University Hospital, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asimakis","family":"Gkremoutis","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Borowski","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7513-5063","authenticated-orcid":false,"given":"Giovanni","family":"Torsello","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, St. Franziskus Hospital M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dittmar","family":"B\u00f6ckler","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2704-3871","authenticated-orcid":false,"given":"Thomas","family":"Zeller","sequence":"additional","affiliation":[{"name":"Clinic Cardiology and Angiology II, Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Steinbauer","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Barmherzige Brueder Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Tsilimparis","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Ludwig-Maximilians-University Hospital, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodosios","family":"Bisdas","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, St. Franziskus Hospital M\u00fcnster, Germany"},{"name":"Department of Vascular and Endovascular Surgery, Athens Medical Center, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzin","family":"Adili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Balzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arend","family":"Billing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Brixner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian E.","family":"Debus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Joachim","family":"Florek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhardt","family":"Grundmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Keck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Ger\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klonek","family":"Wojciech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"M\u00fchling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Oberhuber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Reinecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Reinhold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf-Gerhard","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Schelzig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schlensack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Schmitz-Rixen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Ludwig","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Spohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Storck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Trede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Uhl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Weis-M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner","family":"Wenk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Zhorzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"bibr1-1526602820938465","unstructured":"Saran R, Bruce Robinson, Abbott KC, et al. US Renal Data System 2019 Annual Data Report: Epidemiology of Kidney Disease in the United States. https:\/\/www.ajkd.org\/article\/S0272-6386(19)31009-1\/fulltext. Accessed May 3, 2020."},{"key":"bibr2-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015050542"},{"key":"bibr3-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012010037"},{"key":"bibr4-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-012-0340-4"},{"key":"bibr5-1526602820938465","unstructured":"Chapter 4: Cardiovascular disease in patients with CKD. In: 2018 US RDS Annual Data Report, Volume 1: Chronic Kidney Disease (CKD) in the United States. https:\/\/www.usrds.org\/2018\/view\/Default.aspx. Accessed May 3, 2020."},{"key":"bibr6-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.01.416"},{"key":"bibr7-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2015.07.005"},{"key":"bibr8-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009724"},{"key":"bibr9-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.040"},{"key":"bibr10-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027625"},{"key":"bibr11-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2017.07.005"},{"key":"bibr12-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1177\/1526602818771383"},{"key":"bibr13-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.09.039"},{"key":"bibr14-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.12.048"},{"key":"bibr15-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2014.07.005"},{"key":"bibr16-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000114519.75433.DD"},{"key":"bibr17-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.02.340"},{"key":"bibr18-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.02.016"},{"key":"bibr19-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-017-1673-6"},{"key":"bibr20-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2866"},{"key":"bibr21-1526602820938465","volume":"381","author":"Mohandas R","year":"2019","journal-title":"N Engl J Med"},{"key":"bibr22-1526602820938465","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05600515"},{"key":"bibr23-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1177\/1526602815616924"},{"key":"bibr24-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.10.020"},{"key":"bibr25-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.05.229"},{"key":"bibr26-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.024"},{"key":"bibr27-1526602820938465","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2017.04.020"}],"container-title":["Journal of Endovascular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1526602820938465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1526602820938465","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1526602820938465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:33:39Z","timestamp":1777498419000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1526602820938465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1177\/1526602820938465"],"URL":"https:\/\/doi.org\/10.1177\/1526602820938465","relation":{},"ISSN":["1526-6028","1545-1550"],"issn-type":[{"value":"1526-6028","type":"print"},{"value":"1545-1550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,7]]}}}