{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T22:47:05Z","timestamp":1777848425923,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T00:00:00Z","timestamp":1637366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>We investigated the predictors of major amputation (MA) at 1 year and prepared a scoring model to stratify the clinical outcomes of chronic limb-threatening ischemia (CLTI) patients at wound, ischemia, and foot infection (WIfI) clinical stage 4 after endovascular therapy (EVT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This study was a retrospective, observational study performed at a single center. A total of 353 CLTI patients (390 limbs) were treated with EVT between April 2007 and December 2016. Among these, limbs at WIfI clinical stages 1, 2, and 3 were excluded, and 194 limbs at WIfI clinical stage 4 (49.7%) were enrolled. The primary endpoint was major amputation (MA) free rate at 1 year. Predictors of MA at 1 year was evaluated by Cox proportional hazard analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At 1 year, the incidence of MA was 18.0% (35 limbs). Cox proportional hazard analysis revealed that hemodialysis (hazard ratio [HR] 2.63; 95% confidence interval [CI], 1.24\u20135.58; p=0.012), fI3 (HR 2.54; 95% CI, 1.28\u20135.06; p=0.008), toe wounds (HR 0.29; 95% CI, 0.094\u20130.88; p=0.029), and visible blood flow to the wound (HR 0.43; 95% CI, 0.21\u20130.89; p=0.023) were associated with MA. We assigned 1 point for positive predictors of MA, hemodialysis, and fI3; 1 point was deducted for negative predictors of MA, toe wounds, and visible blood flow to the wound. A score of \u22122 or \u22121, was defined as the low-risk group, 0 was defined as the intermediate-risk group, and +1 or +2 were defined as the high-risk group. At 1 year, MA free rate, wound healing rate, and amputation-free survival rate were stratified according to a scoring model. MA free rate was 96.6% in low-risk, 72.4% in intermediate-risk, and 67.3% in high-risk (p&lt;0.001); wound healing rate was 67.8% in low-risk, 27.6% in intermediate-risk, and 4.1% in high-risk (p&lt;0.001); amputation-free survival rate was 65.3% in low-risk, 44.8% in intermediate-risk, and 18.4% in high-risk (p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The scoring model based on the predictors of MA stratified clinical outcomes in CLTI patients at WIfI clinical stage 4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15266028211059453","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T04:41:43Z","timestamp":1637383303000},"page":"594-601","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Scoring Model to Predict Major Amputation in Patients With Chronic Limb-Threatening Ischemia at Wound, Ischemia, and Foot Infection Clinical Stage 4 After Endovascular Therapy"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1254-0621","authenticated-orcid":false,"given":"Norihiro","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9037-867X","authenticated-orcid":false,"given":"Shinsuke","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-1858","authenticated-orcid":false,"given":"Yohsuke","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigemitsu","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Mizusawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahide","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,20]]},"reference":[{"key":"bibr1-15266028211059453","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202063260605"},{"key":"bibr2-15266028211059453","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-5-14"},{"key":"bibr3-15266028211059453","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005531"},{"key":"bibr4-15266028211059453","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.08.003"},{"key":"bibr5-15266028211059453","volume":"51","author":"Bradbury AW","year":"2010","journal-title":"J Vasc 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