{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T22:47:43Z","timestamp":1777848463251,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Leg muscle microvascular blood flow (perfusion) is impaired in response to maximal exercise in patients with peripheral artery disease (PAD); however, during submaximal exercise, microvascular perfusion is maintained due to a greater increase in microvascular blood volume compared with that seen in healthy adults. It is unclear whether this submaximal exercise response reflects a microvascular impairment, or whether it is a compensatory response for the limited conduit artery flow in PAD. Therefore, to clarify the role of conduit artery blood flow, we compared whole-limb blood flow and skeletal muscle microvascular perfusion responses with exercise in patients with PAD (n=9; 60\u00b17 years) prior to, and following, lower-limb endovascular revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Microvascular perfusion (microvascular volume \u00d7 flow velocity) of the medial gastrocnemius muscle was measured before and immediately after a 5 minute bout of submaximal intermittent isometric plantar-flexion exercise using contrast-enhanced ultrasound imaging. Exercise contraction-by-contraction whole-leg blood flow and vascular conductance were measured using strain-gauge plethysmography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      With revascularization there was a significant increase in whole-leg blood flow and conductance during exercise (p&lt;0.05). Exercise-induced muscle microvascular perfusion response did not change with revascularization (pre-revascularization: 3.19\u00b12.32; post-revascularization: 3.89\u00b11.67 aU.s\n                      <jats:sup>\u22121<\/jats:sup>\n                      ; p=0.38). However, the parameters that determine microvascular perfusion changed, with a reduction in the microvascular volume response to exercise (pre-revascularization: 6.76\u00b13.56; post-revascularization: 2.42\u00b10.69 aU; p&lt;0.01) and an increase in microvascular flow velocity (pre-revascularization: 0.25\u00b10.13; post-revascularization: 0.59\u00b10.25 s\n                      <jats:sup>\u22121<\/jats:sup>\n                      ; p=0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings suggest that patients with PAD compensate for the conduit artery blood flow impairment with an increase in microvascular blood volume to maintain muscle perfusion during submaximal exercise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Impact<\/jats:title>\n                    <jats:p>The findings from this study support the notion that the impairment in conduit artery blood flow in patients with PAD leads to compensatory changes in microvascular blood volume and flow velocity to maintain muscle microvascular perfusion during submaximal leg exercise. Moreover, this study demonstrates that these microvascular changes are reversed and become normalized with successful lower-limb endovascular revascularization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15266028221114722","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T01:23:20Z","timestamp":1658971400000},"page":"115-125","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Toward a Better Understanding of Muscle Microvascular Perfusion During Exercise in Patients With Peripheral Artery Disease: The Effect of Lower-Limb Revascularization"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7542-4535","authenticated-orcid":false,"given":"Annelise","family":"Men\u00eases","sequence":"first","affiliation":[{"name":"VasoActive Research Group, School of Health, University of the Sunshine Coast, Sippy Downs, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Digby","family":"Krastins","sequence":"additional","affiliation":[{"name":"VasoActive Research Group, School of Health, University of the Sunshine Coast, Sippy Downs, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sunshine Coast University Hospital, Birtinya, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Bailey","sequence":"additional","affiliation":[{"name":"VasoActive Research Group, School of Health, University of the Sunshine Coast, Sippy Downs, QLD, Australia"},{"name":"Physiology and Ultrasound Laboratory in Science and Exercise, Centre for Research on Exercise, Physical Activity &amp; Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Quah","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sunshine Coast University Hospital, Birtinya, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaibhav","family":"Sankhla","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sunshine Coast University Hospital, Birtinya, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeng","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sunshine Coast University Hospital, Birtinya, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Sunshine Coast University Hospital, Birtinya, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Schulze","sequence":"additional","affiliation":[{"name":"Sunshine Vascular Clinic, Buderim, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Sunshine Coast University Hospital, Birtinya, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Magee","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Sunshine Coast University Hospital, Birtinya, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Golledge","sequence":"additional","affiliation":[{"name":"Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University and Department of Vascular and Endovascular Surgery, Townsville University Hospital, Townsville, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Greaves","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sunshine Coast University Hospital, Birtinya, QLD, Australia"},{"name":"Sunshine Coast Health Institute, Sunshine Coast Hospital and Health Service, Birtinya, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D.","family":"Askew","sequence":"additional","affiliation":[{"name":"VasoActive Research Group, School of Health, University of the Sunshine Coast, Sippy Downs, QLD, Australia"},{"name":"Sunshine Coast Health Institute, Sunshine Coast Hospital and Health Service, Birtinya, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2281.2002.00400.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00480.2015."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.01.037."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00141.2011."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1980.tb00037.x."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200112000-00007"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13601."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.04.001."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.21767\/2573-4482.100041"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00232.2018."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2013.073874."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.1.H567."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.07.010."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.11.022."},{"issue":"5","key":"e_1_3_3_16_2","first-page":"771","article-title":"Anatomical segmentation in humans and the prediction of segmental masses from intra-segmental anthropometry","volume":"58","author":"Clarys JP","year":"1986","unstructured":"Clarys JP, Marfell-Jones MJ. 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