{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T22:47:50Z","timestamp":1777848470721,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"key research and development plan projects in Anhui province","award":["201904a07020020"],"award-info":[{"award-number":["201904a07020020"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Drug-coated balloon (DCB) angioplasty and laser atherectomy (LA) have been frequently utilized to treat femoropopliteal in-stent restenosis (ISR); however, no studies have concurrently compared available regimens, including DCB, LA+DCB, and LA + plain balloon angioplasty (PB). Therefore, we conducted this network meta-analysis to determine whether there were significant differences in outcomes among these regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A comprehensive search was conducted in PubMed, EMBASE, and the Cochrane library to identify all randomized controlled trials comparing DCB or LA-based regimes with POBA or each other for treating femoropopliteal in-stent restenosis (ISR) from their inception until March 2021. The primary outcome measure was binary restenosis, and secondary outcome measures were target lesion revascularization (TLR) and mortality, evaluated at 6 and 12 months, respectively. Statistical analysis was performed using Aggregate Data Drug Information System (ADDIS) 1.4 software, and all data were graphically summarized using Microsoft Excel software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The final analysis included 11 studies, of which 6 studies compared DCB with PB, 2 studies compared PB vs LA+PB, 2 studies compared DCB vs LA+DCB, and 1 study compared LA+DCB with LA+PB. DCB was better than PB in decreasing binary restenosis at 6 (odds ratio [OR]: 0.22, 95% credible interval [CrI]: 0.04\u20130.91) and 12 (OR: 0.26, 95% CrI: 0.12\u20130.50) months. DCB was associated with lower TLR than PB at 6 months (OR: 0.31, 95% CrI: 0.13\u20130.69). LA+DCB was also superior to PB in treating binary restenosis at 12 months (OR: 6.10, 95% CrI: 1.94\u201324.41) and TLR at 6 months (OR: 5.32, 95% CrI: 1.43\u201328.06). There was no statistical difference in mortality between PB, DCB, and LA+PB. DCB and LA+DCB were the first 2 options for reducing binary restenosis and TLR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The current network meta-analysis demonstrates that both DCB and LA+DCB are superior to PB alone, and that DCB and LA+DCB may be the preferred treatment options for reducing binary restenosis and TLR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Impact<\/jats:title>\n                    <jats:p>The treatment for femoropopliteal in-stent restenosis (ISR) remains challenging clinical practice. One important reason is that no optimal treatment strategy was available. Drug-coated balloon angioplasty (DCB) and laser atherectomy (LA) have been extensively utilized to treat ISR; however, different combinations of these treatments further confused the clinicians\u2019 choices. This network meta-analysis systematically investigated the difference between the currently available treatments regarding therapeutic effects and safety, indicating that DCB and LA+DCB may be the optimal treatment for decreasing the risk of binary restenosis and target lesion revascularization. The results of the current network meta-analysis help to resolve the confusion of clinicians in making the decision.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15266028221125581","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T06:09:43Z","timestamp":1664777383000},"page":"390-399","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Network Meta-Analysis of All Available Regimens Based on Drug-Coated Balloon Angioplasty and Laser Atherectomy for Femoropopliteal In-Stent Restenosis"],"prefix":"10.1177","volume":"31","author":[{"given":"Chaowen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiancai","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4839-0549","authenticated-orcid":false,"given":"Qiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7089-4025","authenticated-orcid":false,"given":"Yong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"bibr1-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1016\/s2214-109x(19)30255-4"},{"key":"bibr2-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1177\/1526602816645080"},{"key":"bibr3-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"bibr4-15266028221125581","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2016.0120"},{"key":"bibr5-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012510.pub2"},{"key":"bibr6-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000470"},{"key":"bibr7-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051303"},{"issue":"3","key":"bibr8-15266028221125581","first-page":"325","volume":"55","author":"Singh GD","year":"2014","journal-title":"J Cardiovasc Surg"},{"key":"bibr9-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.95.8.1998"},{"key":"bibr10-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.02.015"},{"key":"bibr11-15266028221125581","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.S81122"},{"key":"bibr12-15266028221125581","doi-asserted-by":"publisher","DOI":"10.23736\/S0021-9509.17.09963-3"},{"key":"bibr13-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.11.058"},{"key":"bibr14-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.007"},{"key":"bibr15-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2481071159"},{"key":"bibr16-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.118.007055"},{"key":"bibr17-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1583\/13-4538R.1"},{"key":"bibr18-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.031"},{"key":"bibr19-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.111.967802"},{"key":"bibr20-15266028221125581","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1875"},{"key":"bibr21-15266028221125581","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-2-201307160-00008"},{"key":"bibr22-15266028221125581","unstructured":"Higgins JPT, Green S. 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