{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:13:21Z","timestamp":1781090001785,"version":"3.54.1"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Clinical trials have demonstrated the superiority of drug-coated balloon (DCB) to noncoated balloon angioplasty for the treatment of femoropopliteal (FP) lesions. In those trials, the difference of primary patency between DCB and noncoated angioplasty widens especially after 6 months, speculating that the antirestenosis effect of paclitaxel is manifested after 6 months. Factors associated with restenosis after 6 months differ from those associated with restenosis within 6 months. This study aimed to elucidate the prognostic factors associated with early (within 6 months) and late (after 6 months) restenosis following DCB treatment in real-world FP practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This multicenter, retrospective study analyzed 486 FP lesions (mean lesion length, 11.9\u00b110.1 cm; chronic total occlusion, 21.0%) in 423 patients (diabetes mellitus, 59.3%; hemodialysis, 37.1%; chronic limb-threatening ischemia, 41.6%) who underwent successful DCB treatment between January 2018 and December 2019. The outcome measure was restenosis which is defined as a peak systolic velocity ratio &gt;2.4 based on duplex ultrasound findings. Early and late restenosis were classified by the cutoff period of 6 months after the procedure. The associations of baseline and procedural characteristics with early and late restenosis were explored using Cox proportional hazards regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean follow-up period was 25.3\u00b112.1 months. The 6, 12, 18, and 24\u2009month cumulative incidences of restenosis were 7.4%\u00b12.4%, 20.9%\u00b13.9%, 29.9%\u00b14.5%, and 38.4%\u00b15.1%, respectively. During the follow-up period, early and late restenosis was evident in a total of 31 lesions and 138 lesions, respectively. Multivariate analysis revealed that chronic total occlusion (hazard ratio [HR], 2.29; 95% confidence interval [CI], 1.07\u20134.92; p=0.033) and superficial femoral artery ostial lesion (HR, 2.73; 95% CI, 1.28\u20135.80; p=0.009) were significantly associated with early restenosis. On the other hand, calcification circumference over 270\u00b0 (HR, 1.67; 95% CI, 1.17\u20132.37; p=0.004), distal external elastic membrane diameter under 5 mm assessed by intravascular ultrasound (HR, 1.90; 95% CI, 1.29\u20132.79; p=0.001), and involving popliteal arterial lesion (HR, 1.54; 95% CI, 1.08\u20132.21; p=0.017) were significantly associated with late restenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The prognostic factors associated with late restenosis differed from those associated with early restenosis in the real-world FP-DCB practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Impact<\/jats:title>\n                    <jats:p>The current multicenter, retrospective study revealed that factors associated with early restenosis differed from those with late restenosis in the real-world FP-DCB practice. CTO and SFA ostial lesion were associated with early restenosis, while severe calcification, smaller vessel, and involving popliteal arterial lesions were associated with late restenosis.<\/jats:p>\n                    <jats:p>Early restenosis indicates \u201cballoon failure\u201d and would potentially result from recoil, which primary stent implantation might be required. On the other hand, late restenosis after 6 months would be attributed to \u201cDCB failure\u201d, with inadequate drug uptake into the arterial wall, which might be minimized by the use of atherectomy devices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15266028231186717","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T05:03:02Z","timestamp":1689915782000},"page":"746-755","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Factors Associated With Early and Late Restenosis Following Drug-Coated Balloon Treatment for Patients With Femoropopliteal Lesions"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1590-5227","authenticated-orcid":false,"given":"Taku","family":"Toyoshima","sequence":"first","affiliation":[{"name":"Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, 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