{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T14:54:46Z","timestamp":1777820086330,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["Z210012,7212094"],"award-info":[{"award-number":["Z210012,7212094"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012401","name":"Beijing Science and Technology Planning Project","doi-asserted-by":"publisher","award":["Z211100002921048"],"award-info":[{"award-number":["Z211100002921048"]}],"id":[{"id":"10.13039\/501100012401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170498, 81970404"],"award-info":[{"award-number":["82170498, 81970404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To explore the role of location, length, and thickness of the intimal flap in the propagation of Stanford type B aortic dissection (TBAD) based on ex vivo porcine aorta models based on ex vivo porcine aorta models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The porcine aortas were harvested and randomly divided into 6 groups to create various TBAD aortic models. We constructed intimal flaps for different locations (group A [entry tear on outer curvature] and group B [entry tear on inner curvature]), lengths (group C [long] and group D [short]), and thicknesses (group E [thick] and group F [thin]). For the ex vivo perfusion experiments conducted on model aortas, an experimental circulation loop (ECL) was employed. The pressure in false lumen (FL) was constantly monitored. A comparison was made between the morphological data collected before and after the experiment to quantify the changes in the FL after the experiment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Compared the results with group B, the mean peak pressures of the FL in group A were lower (106.87\u00b115.55 vs. 124.01\u00b122.75 mm Hg, p=0.028). The mean axial propagation length in group A was shown to be shorter than that of group B (88.14\u00b133.38 vs. 197.43\u00b141.65 mm, p&lt;0.001). The mean peak pressure was higher in group C than in group D (144.04\u00b119.37 vs. 92.51\u00b126.70 mm Hg, p&lt;0.001). The mean peak pressure of group E was higher than that of group F (160.83\u00b132.83 vs. 109.33\u00b115.62 mm Hg, p&lt;0.001), as was the mean axial propagation length of group E (143.11\u00b139.73 vs. 100.45\u00b135.44 mm, p=0.021). According to the results of multivariable linear regression, axial propagation length=45.873\u20130.703\u00d7length of initial FL+0.863\u00d7 peak pressure (p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There was a relationship between FL propagation and the location, length, and thickness of the intimal flap. The axial propagation length was related to the length of the intimal flap and the peak pressure of propagation. It may be helpful to evaluate the risk of propagation in patients with TBAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Impact<\/jats:title>\n                    <jats:p>This study found that the locations, lengths, and thickness of the intimal flap significantly contributed to propagation pressure of FL. Using dissection flap characteristics, a physician can predict FL development in a patient and formulate a treatment plan.The purpose was to investigate the relationship between the dissection flap characteristics (location, length, and thickness) and the propagation of the FL, which is not clear at present. This study employed porcine models to create an experimental circulation loop. The perfusion experiment was conducted using a FL without distal re-entry and a non-pulsating flow.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15266028231199930","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T04:47:20Z","timestamp":1695185240000},"page":"1214-1223","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Location, Length, and Thickness of the Intimal Flap in the Propagation of Stanford Type B Aortic Dissection Based on Ex Vivo Porcine Aorta Models"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-6101","authenticated-orcid":false,"given":"Shuangjing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Chinese People\u2019s Liberation Army General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heyue","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Emergency Surgery, Peking University People\u2019s Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifu","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Chinese People\u2019s Liberation Army General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Chinese People\u2019s Liberation Army General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Chinese People\u2019s Liberation Army General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-8390","authenticated-orcid":false,"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Chinese People\u2019s Liberation Army General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-4369","authenticated-orcid":false,"given":"Duanduan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Science, Beijing Institute of Technology, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9884-1267","authenticated-orcid":false,"given":"Jiang","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Chinese People\u2019s Liberation Army General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.01.042"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2021.3056022"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)90523-1"},{"issue":"5","key":"e_1_3_3_5_2","first-page":"631","article-title":"Hemodynamic determinants of aortic dissection propagation by 2D computational modeling: implications for endovascular stent-grafting","volume":"53","author":"Chitsaz S","year":"2012","unstructured":"Chitsaz S, Azadani AN, Matthews PB, et al. 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