{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:23:21Z","timestamp":1778826201206,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>In many studies on aortic disease, women are underrepresented. The present study aims to assess sex-specific morphometric differences and gain more insight into endovascular treatment of the ascending aorta (AA) and arch.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Electrocardiogram-gated cardiac computed tomography scans of 116 consecutive patients who were evaluated for transcatheter aortic valve replacement were retrospectively reviewed. Measurements of the AA and aortic arch were made in multiplanar views, perpendicular to the semi-automatic centerline. Multiple linear regression analysis was performed to identify predictors affecting AA and aortic arch diameter in men and women. Propensity score matching was used to investigate whether sex influences aortic morphology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In both sexes, body surface area (BSA) was identified as a positive predictor and diabetes as a negative predictor for aortic diameters. In men, age was identified as a positive predictor and smoking as a negative predictor for aortic diameters. Propensity score matching identified 40 pairs. Systolic and diastolic mean diameters and AA length were significantly wider in men. On average, male aortas were 7.4% wider than female aortas, both in systole and diastole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The present analysis demonstrates that, in women, increased BSA is associated with increased aortic arch diameters, while diabetes is associated with decreased AA and arch diameters. In men, increased BSA and age are associated with increased AA and arch diameters, while smoking and diabetes are associated with decreased AA and arch diameters. Men were confirmed to have 7.4% greater AA and arch diameters than women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Impact<\/jats:title>\n                    <jats:p>Men had 7.4% greater ascending aorta and arch diameters than women in a retrospective cohort, gated computed tomography-based study of 116 patients. Sex-specific differences in ascending aortic and arch size should be considered by aortic endovascular device manufacturers and physicians when developing ascending and arch endografts and planning aortic interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15266028231210228","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T03:13:50Z","timestamp":1699413230000},"page":"1517-1525","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Sex-Specific Morphometric Analysis of Ascending Aorta and Aortic Arch for Planning Thoracic Endovascular Aortic Repair: A Retrospective Cohort Study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-0258","authenticated-orcid":false,"given":"Maria","family":"Katsarou","sequence":"first","affiliation":[{"name":"Houston Methodist DeBakey Heart &amp; Vascular Center, Houston Methodist Hospital, Houston, TX, USA"},{"name":"Section of Vascular Surgery, Cardio Thoracic Vascular Department, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9508-4088","authenticated-orcid":false,"given":"Tim J.","family":"Mandigers","sequence":"additional","affiliation":[{"name":"Section of Vascular Surgery, Cardio Thoracic Vascular Department, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Milan, Italy"},{"name":"Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marton","family":"Berczeli","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart &amp; Vascular Center, Houston Methodist Hospital, Houston, TX, USA"},{"name":"Department of Vascular Surgery, Heart and Vascular Center, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mujeeb Zubair","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart &amp; Vascular Center, Houston Methodist Hospital, Houston, TX, USA"},{"name":"Division of Cardiothoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3236-600X","authenticated-orcid":false,"given":"Viony M.","family":"Belvroy","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart &amp; Vascular Center, Houston Methodist Hospital, Houston, TX, USA"},{"name":"Department of Vascular Surgery, Erasmus Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Bissacco","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1165-5179","authenticated-orcid":false,"given":"Joost A.","family":"van Herwaarden","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santi","family":"Trimarchi","sequence":"additional","affiliation":[{"name":"Section of Vascular Surgery, Cardio Thoracic Vascular Department, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Milan, Italy"},{"name":"Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-6817","authenticated-orcid":false,"given":"Jean","family":"Bismuth","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, LSU School of Medicine, New Orleans, 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