{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:24:54Z","timestamp":1781083494418,"version":"3.54.1"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Endovasc Ther"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study investigated the effect of patency of the pedal arch (PA) on wound healing rate and time, amputation-free survival (AFS), limb salvage, and limb-based patency (LBP) in chronic limb-threatening ischemia (CLTI) patients undergoing endovascular revascularization of infrainguinal arterial lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective study included all CLTI patients presenting with wound, ischemia, and foot infection (WIfI) stages 2 to 4 (WIfI ischemia grades 2-3) who underwent endovascular revascularization of infrainguinal arterial disease between April 2019 and April 2021. Pedal angioplasty was attempted in all patients with significant steno-occlusive pedal artery disease. Patients were stratified according to Kawarada PA types. Successful PA revascularization (PAR) was counted when at least 1 pedal vessel is patent. Wound healing rate and time and Kaplan-Meier estimate of AFS and LBP at 2 years were evaluated and compared among the patient groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 120 patients were categorized according to PA type into type 1 (n = 34; 28.3%), type 2 (n = 64; 53.3%), and type 3 (n = 22; 18.3%). Pedal angioplasty was attempted in 97 patients and was technically successful in 75 patients (77.3%). Successful PAR (with or without pedal angioplasty) was achieved in 98 patients (81.7%). During the follow-up, successful PAR resulted in a better wound healing rate (86.7% vs 59.1%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007), major amputation rates (5.1% vs 40.9%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), and AFS (92.9% vs 72.7%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.018) compared with unsuccessful PAR. There were no significant differences between the 2 groups in wound healing time (3.76 \u00b1 1.99 months vs 3.64 \u00b1 1.94 months;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.798, respectively) or LBP (80.6% vs 72.7%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.594, respectively). Global Limb Anatomic Staging System (GLASS) stage (odds ratio [OR] = 6.84; 95% CI, 1.30-36.03;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.023) and unsuccessful PAR (OR = 21.64; 95% CI, 4.01-116.69;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001) were independently associated with failure of wound healing, whereas site of wound lesion (OR = 5.52; 95% CI, 1.15-26.48;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.033), GLASS stage (OR = 24.93; 95% CI, 2.84-218.69;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004), and unsuccessful PAR (OR = 22.44; 95% CI, 3.53-142.67;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) were significant predictors of major amputation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Successful PAR is important for improving clinical outcomes of endovascular revascularization of CLTI patients such as wound healing, amputation-free survival, and limb salvage. Predictors of limb salvage were site of foot lesion, GLASS stage, and successful PAR, whereas GLASS stage and successful PAR were independently associated with improved wound healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical impact<\/jats:title>\n                    <jats:p>Pedal arch patency positively influences clinical outcomes in patients with chronic limb-threatening ischemia who have ischemic wounds undergoing endovascular revascularization. This study demonstrated that successful pedal arch revascularization (PAR) significantly improved wound healing, amputation-free survival, and limb salvage rates when compared to patients who did not achieve successful PAR. Additionally, the study identified the predictors of limb salvage as the site of foot lesions, GLASS staging, and successful PAR, while both GLASS staging and successful PAR were found to be independently associated with improved wound healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15266028241289034","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T03:04:25Z","timestamp":1730084665000},"page":"1243-1253","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Other Side of the River: Early and Midterm Outcomes of Endovascular Pedal Arch Revascularization in Patients with Chronic Limb-Threatening Ischemia"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7087-8674","authenticated-orcid":false,"given":"Mohammed","family":"Shahat","sequence":"first","affiliation":[{"name":"Vascular Surgery Department, Assiut University Hospital, Faculty of Medicine, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Hassan","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Assiut University Hospital, Faculty of Medicine, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa S","family":"Khalil","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Assiut University Hospital, Faculty of Medicine, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-7826","authenticated-orcid":false,"given":"Ashraf G.","family":"Taha","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Assiut University Hospital, Faculty of Medicine, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elbadawy","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Assiut University Hospital, Faculty of Medicine, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2019.05.006"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00462-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.10.025"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.10.129"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-9590.17.03809-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijves.ijves_64_19"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.08.106"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2021.01.026"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1583\/10-3214.1"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2019.07.034"},{"issue":"6","key":"e_1_3_2_12_2","first-page":"586","article-title":"Angiographic evaluation of the anatomic pattern of arterial obstructions in diabetic patients with critical limb ischaemia","volume":"19","author":"Ciavarella A","year":"1993","unstructured":"Ciavarella A, Silletti A, Mustacchio A, et al. 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