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A detailed informed consent should be obtained from high-risk living kidney donor transplant recipients as well as donors and family members after the high perioperative risk potential has been explained to them. In addition, family members need to be informed of and acknowledge that a living kidney donor transplant recipient with pretransplant extrarenal morbidity has a higher risk of a serious adverse outcome event such as graft failure or recipient death. We review 2 cases involving living kidney donor transplant recipients with significant comorbidity and discuss ethical considerations, donor risk, and the need for an extended informed consent.<\/jats:p>","DOI":"10.1177\/152692480701700304","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T18:01:15Z","timestamp":1484071275000},"page":"180-182","source":"Crossref","is-referenced-by-count":8,"title":["Ethical Issues Surrounding High-Risk Kidney Recipients: Implications for the Living Donor"],"prefix":"10.1177","volume":"17","author":[{"suffix":"Jr","given":"Jerome F.","family":"O'Hara","sequence":"first","affiliation":[{"name":"Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Bramstedt","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stewart","family":"Flechner","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Goldfarb","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,9,1]]},"reference":[{"key":"bibr1-152692480701700304","unstructured":"US Transplant\u2014Scientific Registry of Transplant Recipients. 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