{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:13:00Z","timestamp":1790107980300,"version":"4.0.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Prog Transpl"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute kidney injury is a treatable entity although difficult to recognize without diagnostic biopsy. We investigated the potential association between clinically defined deceased donors and acute kidney injury with preimplantation histological findings and recipient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Kidney biopsies from donors were classified using the Acute Kidney Injury Network criteria and assessed for percentage glomerulosclerosis, tubular atrophy, interstitial fibrosis, and vascular narrowing with the Remuzzi score and for acute tubular necrosis. Differences in incidence rates of delayed graft function (DGF) and cumulative rejection episodes were compared between recipients transplanted with normal and 3 levels of acute kidney injury using the analysis of variance with Bonferroni correction ( P = .0012).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixteen out of 335 donors showed a severe acute kidney injury level 3 with a median serum creatinine of 458 \u00b5mol\/L. Fourteen (88%) had 0-3 Remuzzi score and were used for single kidney transplantation and 2 (12%) were used for dual kidney transplantation (score: 4-6). Recipients who received a kidney from a donor with level 3 acute kidney injury had a higher percentage of DGF (47%) without statistical significance ( P = .008). The rate of cumulative rejection (45%) at 2 years was not significantly increased ( P = .09).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Recipients receiving level 3 acute kidney injury kidneys, selected with Remuzzi histopathological score and acute tubular necrosis assessment, had a greater incidence of DGF but a similar long-term cumulative rejection compared to no injury and level 1 and level 2 acute kidney injury donors. The application of the histopathological examination allowed expansion of the kidney donor pool.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1526924818817054","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T23:02:52Z","timestamp":1544742172000},"page":"36-42","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Histopathology and Long-Term Outcome of Kidneys Transplanted From Donors With Severe Acute Kidney Injury"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-5843","authenticated-orcid":false,"given":"Luca","family":"Cima","sequence":"first","affiliation":[{"name":"Department of Diagnostics and Public Health, Pathology Unit, University and Hospital Trust of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Nacchia","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Kidney Transplant Center, University and Hospital Trust of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ghimenton","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Public Health, Pathology Unit, University and Hospital Trust of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Valotto","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Public Health, Pathology Unit, University and Hospital Trust of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigino","family":"Boschiero","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Kidney Transplant Center, University and Hospital Trust of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gobbo","sequence":"additional","affiliation":[{"name":"Pathology Unit, Pederzoli Hospital of Peschiera Del Garda, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Zaza","sequence":"additional","affiliation":[{"name":"Department of Medicine, Renal Unit, University and Hospital Trust of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desley","family":"Neil","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Pathology Unit, Queen Elizabeth Hospital Birmingham, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Mescoli","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University and Hospital Trust of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Vanzo","sequence":"additional","affiliation":[{"name":"Arsen\u00e0l, Veneto\u2019s Research Center for eHealth Innovation, Veneto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"D\u2019Errico","sequence":"additional","affiliation":[{"name":"Department of Specialised, Experimental and Diagnostic Medicine, Pathology Unit, Sant\u2019Orsola-Malpighi University Hospital, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Ghimenton","sequence":"additional","affiliation":[{"name":"Independent Researcher, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Rugge","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University and Hospital Trust of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Casartelli-Liviero","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Neurosurgery and Intensive Care Unit, University and Hospital Trust of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Brunelli","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Public Health, Pathology Unit, University and Hospital Trust of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Novelli","sequence":"additional","affiliation":[{"name":"Pathology Unit, Carreggi University Hospital, Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albino","family":"Eccher","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Public Health, Pathology Unit, University and Hospital Trust of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"key":"bibr1-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.09.067"},{"key":"bibr2-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.12.020"},{"key":"bibr3-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318279153c"},{"key":"bibr4-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2014.11.002"},{"key":"bibr5-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2013.12.016"},{"key":"bibr6-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12425"},{"key":"bibr7-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-1127-5"},{"key":"bibr8-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13144"},{"key":"bibr9-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13260"},{"key":"bibr10-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13966"},{"key":"bibr11-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000173798.04043.AF"},{"key":"bibr12-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.160"},{"key":"bibr13-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-016-0220-z"},{"key":"bibr14-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-1150-6"},{"key":"bibr15-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1159\/000478264"},{"key":"bibr16-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12928"},{"key":"bibr17-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13213"},{"key":"bibr18-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000173801.33878.BF"},{"key":"bibr19-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000250908.62948.8f"},{"key":"bibr20-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.06.036"},{"key":"bibr21-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02505.x"},{"key":"bibr22-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13867"},{"key":"bibr23-1526924818817054","author":"Cima L","year":"2018","journal-title":"Progress in Transplantation"},{"key":"bibr24-1526924818817054","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.876348"},{"key":"bibr25-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1186\/cc5713"},{"key":"bibr26-1526924818817054","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08270813"},{"key":"bibr27-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052891"},{"key":"bibr28-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02394.x"},{"key":"bibr29-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012111081"},{"key":"bibr30-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12400"},{"key":"bibr31-1526924818817054","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13929"}],"container-title":["Progress in Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1526924818817054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1526924818817054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1526924818817054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:39:55Z","timestamp":1777700395000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1526924818817054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,13]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1177\/1526924818817054"],"URL":"https:\/\/doi.org\/10.1177\/1526924818817054","relation":{},"ISSN":["1526-9248","2164-6708"],"issn-type":[{"value":"1526-9248","type":"print"},{"value":"2164-6708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,13]]}}}