{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:15:49Z","timestamp":1777940149303,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Prog Transpl"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Posttransplant lymphoproliferative disorder (PTLD) is a severe complication after kidney transplantation. This study examined the incidence, risk factors, clinical management, and outcomes of PTLD in a cohort of kidney transplant recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This single-center cohort study included 1642 patients transplanted from January 1, 2000, to December 31, 2012, with follow-up until December 31, 2013. The incidence and risk factors for PTLD were examined using a Cox proportional hazards model. A Cox model was also used to assess the association of PTLD and graft outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixteen recipients developed PTLD over follow-up. The incidence rate was 0.18 (95% confidence interval [CI]: 0.11-0.29) cases per 100 person-years. Four were from Epstein\u2013Barr virus (EBV) mismatched (D+\/R\u2212) transplants and 12 from EBV-positive recipients (R+). Recipients with D+\/R\u2212 matches were at a significantly higher risk of developing PTLD than R+ (hazard ratio [HR]: 7.52 [95% CI: 2.42-23.32]). Fifteen cases had immunosuppression reduced, 11 cases were supplemented with rituximab or ganciclovir, 6 cases required chemotherapy or radiation, and 6 cases had tumors excised. By the end of follow-up, 6 patients went into remission, 5 returned to chronic dialysis, and 5 patients died. Patients with PTLD were significantly more likely to have total graft failure (return to chronic dialysis, preemptive retransplant, or death with graft function) than patients without PTLD (HR: 3.41 [95% CI: 1.72-6.78).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Epstein\u2013Barr virus mismatch continues to be a strong risk factor for developing PTLD after kidney transplantation. Recipients with PTLD have a poor prognosis, as the optimal management remains to be elucidated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1526924819835834","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T23:17:06Z","timestamp":1552000626000},"page":"185-193","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Incidence, Risk Factors, Clinical Management, and Outcomes of Posttransplant Lymphoproliferative Disorder in Kidney Transplant Recipients"],"prefix":"10.1177","volume":"29","author":[{"given":"Michelle","family":"Liu","sequence":"first","affiliation":[{"name":"Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahid","family":"Husain","sequence":"additional","affiliation":[{"name":"Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada"},{"name":"Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olusegun","family":"Famure","sequence":"additional","affiliation":[{"name":"Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Li","sequence":"additional","affiliation":[{"name":"Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Joseph","family":"Kim","sequence":"additional","affiliation":[{"name":"Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada"},{"name":"Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"bibr1-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1016\/j.carj.2013.06.002"},{"key":"bibr2-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12533"},{"key":"bibr3-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2016.03.045"},{"key":"bibr4-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12744"},{"key":"bibr5-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(03)00668-7"},{"key":"bibr6-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13087"},{"key":"bibr7-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12167"},{"key":"bibr8-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1392-x"},{"issue":"4","key":"bibr9-1526924819835834","doi-asserted-by":"crossref","first-page":"196","DOI":"10.25100\/cm.v47i4.1989","volume":"47","author":"Nieto-Rios JF","year":"2016","journal-title":"Colomb Med"},{"key":"bibr10-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2015.04.003"},{"key":"bibr11-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000231752.50587.ae"},{"key":"bibr12-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03478.x"},{"key":"bibr13-1526924819835834","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.132209"},{"key":"bibr14-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000173793.03228.bd"},{"key":"bibr15-1526924819835834","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2012.0204"},{"key":"bibr16-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.02.018"},{"key":"bibr17-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3627-2"},{"issue":"2","key":"bibr18-1526924819835834","first-page":"110","volume":"48","author":"Fellner MD","year":"2016","journal-title":"Rev Argent Microbiol"},{"key":"bibr19-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12605"},{"key":"bibr20-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001201"},{"key":"bibr21-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.04.010"},{"key":"bibr22-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv260"},{"key":"bibr23-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12072"},{"key":"bibr24-1526924819835834","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009053548"},{"key":"bibr25-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.03.017"},{"key":"bibr26-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12392"},{"key":"bibr27-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.197"},{"key":"bibr28-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12375"},{"key":"bibr29-1526924819835834","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcmf.2013.11.002"}],"container-title":["Progress in Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1526924819835834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1526924819835834","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1526924819835834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:40:01Z","timestamp":1777700401000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1526924819835834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,7]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1177\/1526924819835834"],"URL":"https:\/\/doi.org\/10.1177\/1526924819835834","relation":{},"ISSN":["1526-9248","2164-6708"],"issn-type":[{"value":"1526-9248","type":"print"},{"value":"2164-6708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,7]]}}}