{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:35Z","timestamp":1789609235684,"version":"build-2803163510"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Prog Transpl"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>Human leukocyte antigen allosensitization prior to transplant can increase the risk of early graft loss and prolong waitlist times for intestinal transplant candidates. Desensitization offers a potential therapeutic option to reduce the quantity of preformed antibodies prior to organ allocation and facilitate transplantation with a more immunologically compatible donor allograft. However, there remains a paucity of data to guide the use of desensitization in the setting of intestinal transplantation. As a result, in this review we evaluate the existing literature supporting the role of desensitization therapy in intestinal transplant, describe our own experience with the implementation of a risk-stratified desensitization protocol, and finally explore barriers and unanswered questions that continue to limit the widespread adoption of desensitization as a management strategy for highly sensitized intestinal transplant candidates.<\/jats:p>","DOI":"10.1177\/1526924819855088","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:12:24Z","timestamp":1559866344000},"page":"275-278","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Is There a Role for Desensitization in Intestinal Transplantation?"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4575-5330","authenticated-orcid":false,"given":"Andrew D.","family":"Santeusanio","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Mount Sinai Hospital, New York, NY, USA"},{"name":"Recanati Miller Transplantation Institute, Intestinal Transplant Program, Mount Sinai Hospital, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang","family":"Moon","sequence":"additional","affiliation":[{"name":"Recanati Miller Transplantation Institute, Intestinal Transplant Program, Mount Sinai Hospital, New York, NY, USA"},{"name":"Department of Surgery, Mount Sinai Hospital, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Nephrology, North Shore University Hospital, Manhasset, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore R.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Recanati Miller Transplantation Institute, Intestinal Transplant Program, Mount Sinai Hospital, New York, NY, USA"},{"name":"Department of Surgery, Mount Sinai Hospital, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"bibr1-1526924819855088","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04332.x"},{"key":"bibr2-1526924819855088","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000226078.94635.76"},{"key":"bibr3-1526924819855088","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000145878.92906.9F"},{"key":"bibr4-1526924819855088","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v8.i1.101"},{"key":"bibr5-1526924819855088","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181d21e7f"},{"key":"bibr6-1526924819855088","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13050"},{"key":"bibr7-1526924819855088","volume-title":"ISBTS 2013 Symposium","author":"Kaneku H","year":"2013"},{"key":"bibr8-1526924819855088","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182888df0"},{"key":"bibr9-1526924819855088","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2012.01657.x"},{"key":"bibr10-1526924819855088","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04237.x"}],"container-title":["Progress in Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1526924819855088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1526924819855088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1526924819855088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:40:07Z","timestamp":1777700407000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1526924819855088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,6]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1177\/1526924819855088"],"URL":"https:\/\/doi.org\/10.1177\/1526924819855088","relation":{},"ISSN":["1526-9248","2164-6708"],"issn-type":[{"value":"1526-9248","type":"print"},{"value":"2164-6708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,6]]}}}