{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:16:43Z","timestamp":1777940203519,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T00:00:00Z","timestamp":1662249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Prog Transpl"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Introduction: The occurrence of simultaneous liver kidney transplantation has greatly increased; however, the ideal induction and maintenance immunosuppression remains unknown. Question: This evaluation aimed to determine if corticosteroid only induction in simultaneous liver kidney transplant recipients provided adequate prophylaxis against rejection when compared to basiliximab. Design: This was a single center, retrospective, cohort study of adult simultaneous liver kidney transplant recipients from June 2010 to June 2019 receiving corticosteroid only (N\u2009=\u200941) or basiliximab (N\u2009=\u200942) induction. Results: Liver or kidney biopsy proven acute rejection at 3 months was comparable between the corticosteroid only and basiliximab groups (10% vs 7%, P\u2009=\u2009.67), which persisted through 12 months posttransplant (15% vs 21%, P\u2009=\u2009.42). The occurrence of any infection at 3 months was increased in the corticosteroid only group relative to the basiliximab group (41% vs 21%, P\u2009=\u2009.049). Graft and patient survival at 12 months were similar between groups. Maintenance immunosuppression was overall minimized with a tacrolimus goal of 6-8\u2005ng\/mL, mycophenolate mofetil dose reduction to 1000\u2005mg\/day by 3 months, and early steroid withdrawal in both groups. Conclusion: Our findings suggested that corticosteroid only induction was an effective strategy for preventing rejection in simultaneous liver kidney transplant recipients, even in combination with reduced maintenance immunosuppression.<\/jats:p>","DOI":"10.1177\/15269248221122883","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T02:27:10Z","timestamp":1662344830000},"page":"363-369","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Steroid Only Induction on Rejection in Simultaneous Liver-Kidney Transplantation"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7742-2621","authenticated-orcid":false,"given":"Irene","family":"Ruiz","sequence":"first","affiliation":[{"name":"Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Sparkes","sequence":"additional","affiliation":[{"name":"Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Masters","sequence":"additional","affiliation":[{"name":"Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Barth","sequence":"additional","affiliation":[{"name":"Surgery, University of Maryland Medical Center, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Maluf","sequence":"additional","affiliation":[{"name":"Surgery, University of Maryland Medical Center, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sari","family":"Freedman","sequence":"additional","affiliation":[{"name":"Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,4]]},"reference":[{"key":"bibr1-15269248221122883","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16978"},{"key":"bibr2-15269248221122883","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16982"},{"key":"bibr3-15269248221122883","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25390"},{"key":"bibr4-15269248221122883","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31817fc2b8"},{"key":"bibr5-15269248221122883","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002768"},{"key":"bibr6-15269248221122883","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02987.x"},{"key":"bibr7-15269248221122883","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14036"},{"key":"bibr8-15269248221122883","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.8.735"},{"key":"bibr9-15269248221122883","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25726"},{"key":"bibr10-15269248221122883","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12303"}],"container-title":["Progress in Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15269248221122883","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15269248221122883","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15269248221122883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:41:48Z","timestamp":1777700508000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15269248221122883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1177\/15269248221122883"],"URL":"https:\/\/doi.org\/10.1177\/15269248221122883","relation":{},"ISSN":["1526-9248","2164-6708"],"issn-type":[{"value":"1526-9248","type":"print"},{"value":"2164-6708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,4]]}}}