{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:17:11Z","timestamp":1777940231666,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Prog Transpl"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Introduction: An inverse relationship has been identified between tacrolimus serum concentrations and donor-derived cell-free DNA (dd-cfDNA) levels after lung transplant, but limited data exists on this relationship in the kidney transplant population. Project Aim: The purpose of this evaluation was to examine the relationship between high tacrolimus variability and elevated dd-cfDNA levels in kidney and simultaneous pancreas-kidney transplant recipients at a single center. Design: Single-center, retrospective, descriptive comparative evaluation of kidney and pancreas-kidney transplant recipients who received longitudinal ddcfDNA surveillance. Intrapatient tacrolimus variability was assessed using the coefficient of variation (%CV) measured between 1 and 12 months posttransplant. Pediatrics, retransplant or multiorgan transplant recipients, and pregnant recipients were excluded. Results: One hundred fifteen recipients with 518 dd-cfDNA levels and 3028 tacrolimus troughs were assessed. Pancreas-kidney recipients had significantly higher median dd-cfDNA (0.29% vs. 0.18%, P\u2009=\u2009.034) and were excluded from analysis. Ninety-nine kidney transplant recipients were included for analysis. Recipients with tacrolimus %CV \u226530 ( N\u2009=\u200966) had significantly higher median dd-cfDNA than %CV &lt;30 (0.22% vs. 0.17%, P\u2009=\u2009.031). Tacrolimus %CV \u226530 demonstrated higher median peak dd-cfDNA than %CV &lt;30, though this was not statistically significant (0.36% vs. 0.28%, P\u2009=\u2009.058). Conclusion: These data demonstrated that high intrapatient tacrolimus variability may be associated with elevated dd-cfDNA in the first year after kidney transplant.<\/jats:p>","DOI":"10.1177\/15269248241288559","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T04:12:29Z","timestamp":1728360749000},"page":"204-210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["High Intrapatient Tacrolimus Variability and Increased Cell-Free DNA in Kidney Transplant Recipients"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-2203","authenticated-orcid":false,"given":"Miranda","family":"Kopfman","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Rush University Medical Center, Chicago, IL, USA"},{"name":"Department of Pharmacy Services, Ralph H. Johnson VAMC, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa","family":"Brokhof","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shree","family":"Patel","sequence":"additional","affiliation":[{"name":"CareDx Incorporated, Brisbane, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Fu","sequence":"additional","affiliation":[{"name":"CareDx Incorporated, Brisbane, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5911-135X","authenticated-orcid":false,"given":"Oyedolamu","family":"Olaitan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"bibr1-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15339"},{"key":"bibr2-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003651"},{"key":"bibr3-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.11.034"},{"key":"bibr4-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq096"},{"key":"bibr5-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001040"},{"key":"bibr6-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-019-02643-y"},{"issue":"4","key":"bibr7-15269248241288559","volume":"40","author":"Charya A","year":"2021","journal-title":"J Heart Lung Transplant"},{"issue":"6","key":"bibr8-15269248241288559","volume":"23","author":"George R","year":"2023","journal-title":"Am J Transplant"},{"key":"bibr9-15269248241288559","unstructured":"Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). OPTN\/SRTR 2021 Annual Data Report. U.S. Department of Health and Human Services, Health Resources and Services Administration; 2024. Accessed August 15, 2024. http:\/\/srtr.transplant.hrsa.gov\/annual_reports\/Default.aspx."},{"key":"bibr10-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15199"},{"key":"bibr11-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2016.07.003"},{"key":"bibr12-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1373\/jalm.2016.022731"},{"key":"bibr13-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14402"},{"key":"bibr14-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004267"},{"key":"bibr15-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15822"},{"key":"bibr16-15269248241288559","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15416"}],"container-title":["Progress in Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15269248241288559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15269248241288559","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15269248241288559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:42:23Z","timestamp":1777700543000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15269248241288559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,8]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1177\/15269248241288559"],"URL":"https:\/\/doi.org\/10.1177\/15269248241288559","relation":{},"ISSN":["1526-9248","2164-6708"],"issn-type":[{"value":"1526-9248","type":"print"},{"value":"2164-6708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,8]]}}}