{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:17:19Z","timestamp":1777940239094,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Prog Transpl"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Intrapatient variability (IPV) of tacrolimus and its predictors post-lung transplant are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Project Aims<\/jats:title>\n                    <jats:p>This program evaluation aimed to characterize the IPV of immediate-release versus LCP-tacrolimus and predictors of variability \u226530% in lung transplant recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Adult lung transplant recipients who received immediate-release- or LCP-tacrolimus from January 2016 through August 2023 were included in this single-center retrospective evaluation. Immediate-release- and LCP-tacrolimus groups were matched 2:1 by time from transplant, presence of azole antifungal, and ethnicity. Three previously published equations calculated IPV. Outcomes to determine clinical impact of tacrolimus variability included de novo donor-specific antibody (DSA) development, rejection, graft loss\/mortality, eGFR &lt;60\u2005mL\/min, infection. Time in therapeutic range was assessed. Data were analyzed to determine predictors of variability \u226530%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no significant differences in the variability of immediate-release- versus LCP-tacrolimus among 3 equations used. There was no difference in de novo DSA development, rejection, graft loss, mortality, eGFR &lt;60\u2005mL\/min, or infection between groups. Recipients with rejection during follow-up had higher variability compared to those who did not (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.04). Presence of CYP34A inhibition predicted variability &gt;30% in multivariate analysis. Immediate-release tacrolimus had higher time in therapeutic range versus LCP-tacrolimus, 67% versus 33%, (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.15).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The IPV and associated clinical outcomes of immediate-release versus LCP-tacrolimus in lung transplant recipients did not significantly differ. Development of acute cellular rejection within 1 year follow-up was associated with higher tacrolimus variability regardless of formulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15269248251349773","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T06:43:52Z","timestamp":1750142632000},"page":"183-189","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Intrapatient Variability of IR-Tacrolimus Versus LCP-Tacrolimus in a Cohort of Lung Transplant Recipients"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5149-1733","authenticated-orcid":false,"given":"Hannah","family":"Peterson","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy and Pharmacy Services, University Health System, San Antonio, TX, USA"},{"name":"Division of Pharmacotherapy, College of Pharmacy, The University of 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1162-6362","authenticated-orcid":false,"given":"Joelle","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Pharmacy Services, University Health System, San Antonio, TX, USA"},{"name":"Division of Pharmacotherapy, College of Pharmacy, The University of Texas, Austin, TX, USA"},{"name":"Pharmacotherapy Education and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"},{"name":"University Health Transplant Institute, University Health System, San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-9891","authenticated-orcid":false,"given":"Reed","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Pharmacy Services, University Health System, San Antonio, TX, USA"},{"name":"Division of Pharmacotherapy, College of Pharmacy, The University of Texas, Austin, TX, USA"},{"name":"Pharmacotherapy Education and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"},{"name":"University Health Transplant Institute, University Health System, San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8412-0803","authenticated-orcid":false,"given":"Lara","family":"Jones","sequence":"additional","affiliation":[{"name":"University Health Transplant Institute, University Health System, San Antonio, TX, USA"},{"name":"Division of Pulmonary Diseases and Critical Care, University of Texas Health Science Center San Antonio, San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5685-7028","authenticated-orcid":false,"given":"Holly","family":"Keyt","sequence":"additional","affiliation":[{"name":"University Health Transplant Institute, University Health System, San Antonio, TX, USA"},{"name":"Division of Pulmonary Diseases and Critical Care, University of Texas Health Science Center San Antonio, San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6737-7505","authenticated-orcid":false,"given":"Elisabeth","family":"Kincaide","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Pharmacy Services, University Health System, San Antonio, TX, USA"},{"name":"Division of Pharmacotherapy, College of Pharmacy, The University of Texas, Austin, TX, USA"},{"name":"Pharmacotherapy Education and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"},{"name":"University Health Transplant Institute, University Health System, San Antonio, TX, 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OPTN\/SRTR 2021 annual data report: pancreas. Am J Transplant. 2023;23(2 Suppl 1):S121-S177. doi:https:\/\/doi.org\/10.1016\/j.ajt.2023.02.005","journal-title":"Am J Transplant"},{"issue":"2","key":"e_1_3_3_3_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajt.2023.02.009","article-title":"OPTN\/SRTR 2021 annual data report: Lung","volume":"23","author":"Valapour M","year":"2023","unstructured":"Valapour M, Lehr CJ, Schladt DP, et al. OPTN\/SRTR 2021 annual data report: Lung. Am J Transplant. 2023;23(2 Suppl 1):S379-S442. doi:https:\/\/doi.org\/10.1016\/j.ajt.2023.02.009","journal-title":"Am J Transplant"},{"issue":"2","key":"e_1_3_3_4_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajt.2023.02.006","article-title":"OPTN\/SRTR 2021 annual data report: Liver","volume":"23","author":"Kwong AJ","year":"2023","unstructured":"Kwong AJ, Ebel NH, Kim WR, et al. OPTN\/SRTR 2021 annual data report: Liver. 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