{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:48:01Z","timestamp":1782816481116,"version":"3.54.5"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Prog Transpl"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Rabbit anti-thymocyte globulin (rATG) induction ideal dosing strategies in kidney transplant recipients have not been fully elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Project Aims<\/jats:title>\n                    <jats:p>This study compares the impact of ideal body weight-based versus actual body weight-based rATG dosing on drug purchasing costs and kidney transplant outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective, single-center chart review of kidney transplant recipients receiving rATG induction using (1) actual body weight-based dosing between May 17, 2019, and Mar 13, 2020, versus (2) ideal body weight-based dosing between May 17, 2022, and Mar 13, 2023. The primary endpoint is the rATG drug cost\/kidney transplant recipient [measured by average wholesale price] compared between cohorts. Secondary endpoints are rates of biopsy-proven acute rejection, readmissions secondary to infection, myelosuppression (leukopenia or neutropenia), and viremia (Epstein-Barr virus, cytomegalovirus, and BK virus) measured for 6 months. Study design adhered to EQUATOR STROBE guidelines for reporting cohort studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, rATG ideal body weight-based dosing resulted in a median $3838 saved per kidney transplant recipients, based on average wholesale price, and a statistically significant reduction in cost versus actual body weight-based dosing (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.02). Secondary outcomes were generally similar between groups, with a difference in Epstein-Barr viremia (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.017) not translating to a significant difference in readmissions for infection (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.226).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our institution conducts around 250 kidney transplants annually, and considering the majority will receive rATG induction, this dosing protocol estimates average wholesale price drug purchasing cost-savings of about $900\u2005000\/year without compromising early clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15269248261456512","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:42:29Z","timestamp":1780576949000},"page":"74-80","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost-Savings Realized Using Rabbit Anti-Thymocyte Globulin Ideal Body Weight Dosing for Kidney Transplantation Induction Immunosuppression"],"prefix":"10.1177","volume":"36","author":[{"given":"Christy","family":"Ilia","sequence":"first","affiliation":[{"name":"Hospital of the University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-276X","authenticated-orcid":false,"given":"Ciara","family":"Walshe","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"},{"name":"Penn Transplant Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"},{"name":"Penn Transplant Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Sammons","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"},{"name":"Penn Transplant Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"Norris","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"},{"name":"Penn Transplant Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Forte","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"},{"name":"Penn Transplant Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4370-3796","authenticated-orcid":false,"given":"Jennifer","family":"Trofe","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"},{"name":"Penn Transplant Institute"},{"name":"Division of Renal and Hypertension, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Perelman School of Medicine, University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6321-501X","authenticated-orcid":false,"given":"Gregory","family":"Malat","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania"},{"name":"Penn Transplant Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14582"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.21.159"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2025.102198"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2015.0197"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/15269248211003257"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14372"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040297"},{"key":"e_1_3_3_9_2","unstructured":"Thymoglobulin. Package insert. Genzyme Corporation; 2024."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40472-022-00384-z"},{"issue":"3","key":"e_1_3_3_11_2","article-title":"Changes in cold ischemia time and transplantation practices with the concentric model of kidney allocation [abstract]","volume":"22","author":"Puttarajappa CM","year":"2022","unstructured":"Puttarajappa CM, Sood P, Tevar A, Gunabushanam V, Hariharan S, Mohan S. Changes in cold ischemia time and transplantation practices with the concentric model of kidney allocation [abstract]. Am J Transplant. 2022;22(suppl 3). Accessed January 28, 2025. https:\/\/atcmeetingabstracts.com\/abstract\/changes-in-cold-ischemia-time-and-transplantation-practices-with-the-concentric-model-of-kidney-allocation\/.","journal-title":"Am J Transplant"}],"container-title":["Progress in Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15269248261456512","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15269248261456512","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15269248261456512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:34:14Z","timestamp":1782815654000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15269248261456512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/15269248261456512"],"URL":"https:\/\/doi.org\/10.1177\/15269248261456512","relation":{},"ISSN":["1526-9248","2164-6708"],"issn-type":[{"value":"1526-9248","type":"print"},{"value":"2164-6708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}