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Utilizing a modified Agency for Healthcare Research and Quality stakeholder analysis tool, this study categorized key stakeholders into four main groups: healthcare providers, law enforcement officers, health policy officials, and community leaders. Through in-depth, semistructured interviews with 15 stakeholders recruited from Boston's Mayor's Task Force for Opioid Remediation, we synthesized insights to map out strategic intelligence essential for policy formulation and enhanced stakeholder engagement. The analysis highlighted the necessity of multisector collaboration and identified critical leverage points that could influence future interventions. The findings underscored the potential of tailored interventions that consider the unique needs and contributions of different stakeholder groups, advocating for policy reforms that support comprehensive public health strategies. The integrated framework represents a proposed implementation model for Boston, demonstrating adaptability for other urban settings. The framework introduces innovative strategies for continuous improvement and adaptation, informed by stakeholder feedback. This research contributes to the field by demonstrating the effectiveness of stakeholder analysis in developing actionable and sustainable public health policies, providing a replicable model for other urban settings facing similar public health challenges.<\/jats:p>","DOI":"10.1177\/15271544251370699","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:40:28Z","timestamp":1756993228000},"page":"238-255","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Navigating Complexities: A Comprehensive Stakeholder Analysis for Opioid Crisis Strategies in Boston"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3249-9101","authenticated-orcid":false,"given":"Evans F.","family":"Kyei","sequence":"first","affiliation":[{"name":"Manning College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, USA"},{"name":"Center for Substance Use Research and Related Conditions, Capstone College of Nursing, The University of Alabama, Tuscaloosa, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akwasi","family":"Duah","sequence":"additional","affiliation":[{"name":"Graduate School of Nursing, UMass Chan Medical School, Worcester, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8079-3963","authenticated-orcid":false,"given":"Rockson","family":"Ansong","sequence":"additional","affiliation":[{"name":"Manning College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, USA"},{"name":"College of Humanities and Social Science, Louisiana State University, Baton Rouge, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7891-9513","authenticated-orcid":false,"given":"Grace K.","family":"Kyei","sequence":"additional","affiliation":[{"name":"Manning College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Manning College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_3_2_2_1","unstructured":"Agency for Healthcare Research and Quality. 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Tackling the opioid crisis requires a whole-of-government society-wide approach. https:\/\/www.americanprogress.org\/article\/tackling-the-opioid-crisis-requires-a-whole-of-government-society-wide-approach\/"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108009"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000909"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.9790\/0837-1312024"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000717"},{"key":"e_1_3_2_16_1","unstructured":"City of Boston. (2024 May 1). $1 million in grant funding available to prevent overdose deaths and expand treatment. 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