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Male mice became infected with the reference strain M379 at a dose 1000 times lower than that required to produce the same type of infection in female mice. Male mice developed lesions 2 or 3 months earlier than female. The dose-dependent severity of lesions was confirmed in 22 previously frozen\n                      <jats:italic toggle=\"yes\">L. mexicana<\/jats:italic>\n                      isolates obtained from patients with either localized or diffuse forms of the disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      We concluded that DCL caused by\n                      <jats:italic toggle=\"yes\">L. mexicana<\/jats:italic>\n                      is a severe form of tegumentary leishmaniasis caused by a high parasite inoculum dose in susceptible hosts, with increased susceptibility in males.\n                    <\/jats:p>\n                  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