{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:32:12Z","timestamp":1792801932888,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vector-Borne and Zoonotic Diseases"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Crimean-Congo Hemorrhagic Fever (CCHF) is a zoonotic tick-borne disease endemic in T\u00fcrkiye with expanding geographic distribution. Pediatric data remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study included children (&lt;18 years) with Polymerase chain reaction (PCR) and\/or Immunoglobulin M (IgM)-confirmed CCHF hospitalized in a tertiary referral center in eastern T\u00fcrkiye between January 2021 and December 2022. Demographic, epidemiological, clinical, and laboratory data were obtained from electronic medical records using a standardized data collection form. Patients were grouped according to ribavirin use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-one children were included; 85% were male. The mean age was 164.7 \u00b1 44.7 months. The mean duration of hospitalization was 10.1 \u00b1 2.9 days. Most patients (90%) were involved in animal husbandry, and 57% reported self-removal of ticks. Generalized fatigue (100%), fever (95%), and headache\/myalgia (66.7%) were the most common symptoms. The mean duration of fever was 2.62 \u00b1 1.43 days. Hemorrhagic manifestations occurred in 42.9% of patients. Thrombocytopenia developed in 81% of cases. Ribavirin was administered in 72% of patients, with varying durations. No statistically significant difference was observed between ribavirin groups in terms of hospitalization duration or fever duration. However, a shorter duration of cytopenias was observed in the short-course (2\u20137 days) group. No patients required intensive care unit admission, and no mortality occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Pediatric CCHF in endemic regions is strongly associated with environmental and behavioral exposures, particularly livestock contact and tick handling. The disease course appears milder compared to adults, with excellent outcomes under supportive care. Ribavirin use was not associated with improved clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15303667261449283","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:23:04Z","timestamp":1778131384000},"page":"490-495","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiology and Clinical Outcomes of Pediatric Crimean-Congo Hemorrhagic Fever in Eastern Anatolia, Turkey: A Retrospective Cohort Study"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3574-0370","authenticated-orcid":false,"given":"Esra","family":"Cakmak Taskin","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases, Erzurum Training and Research Hospital, Erzurum, Turkey."},{"name":"Pediatric Infectious Diseases, Kocaeli City Hospital, \u0130zmit, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10050928"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2021.102011"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26285"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.61445"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz328"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.26719\/2024.30.8.570"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000281"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/mra.00749-24"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2024.0066"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1179\/146532809X401999"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2669-8035"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/422000"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.5152\/kd.2016.02"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13090770"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2021.100290"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-2001-82"},{"issue":"2","key":"e_1_3_2_18_1","first-page":"416","article-title":"Value of ABO blood group in predicting the severity of children with Crimean-Congo hemorrhagic fever","volume":"7","author":"G\u00fcven AS","year":"2014","unstructured":"G\u00fcven AS, , Sancakdar E, , Kaya A, et al. Value of ABO blood group in predicting the severity of children with Crimean-Congo hemorrhagic fever. Int J Clin Exp Med, 2014; 7(2):416\u2013420.","journal-title":"Int J Clin Exp Med"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2024.102591"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/JVBD.JVBD_143_21"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-85873-8"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2025.2465315"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens14080785"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2025.102806"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S410955"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.23-0630"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2024.107141"},{"key":"e_1_3_2_28_1","volume-title":"Crimean-Congo Hemorrhagic Fever Case Management Guide","author":"T.C. 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