{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:28:39Z","timestamp":1777940919205,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Medical Scientific Research Project of Jiangsu Provincial Commission Health and Family Planning","award":["H2017048"],"award-info":[{"award-number":["H2017048"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the diagnostic value of radial endobronchial ultrasound (R-EBUS) combination with rapid on-site evaluation (ROSE) guided transbronchial lung biopsy (TBLB) for peripheral pulmonary lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Peripheral pulmonary lesions identified by computed tomography underwent R-EBUS with or without ROSE randomly from February 2016 to August 2017. The diagnostic yield and the operation time were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total, 158 patients were involved in and completed this research, including 84 cases in the group of R-EBUS with ROSE, and 74 in the group without ROSE. The diagnostic yield of ROSE group was 85.7%. Among these positive cases, 69.4% cases were malignant tumors, and 30.6% cases were benign lesions. The operation time was (24.6 \u00b1 6.3) min. In the group without ROSE, the diagnostic yield was 70.3%, including 35 malignant tumors (67.3%), and 17 benign lesions (32.7%). The operation time was (31.5 \u00b1 6.8) min. There were significant differences between both groups in the diagnostic yield (\u03c72 = 5.556, P = 0.018) and in the operation time (t = 3.187, P &lt; 0.01). No serious procedure related complications were observed, such as pneumothorax and hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>ROSE can improve the diagnostic yield, and shorten the operation time. R-EBUS combined with ROSE is a safe and effective technique for peripheral pulmonary lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533033820947482","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T07:56:59Z","timestamp":1597823819000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Rapid On-Site Evaluation During Radial Endobronchial Ultrasound\u2013Guided Transbronchial Lung Biopsy for the Diagnosis of Peripheral Pulmonary Lesions"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-2183","authenticated-orcid":false,"given":"Chunhua","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huidi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rusong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"issue":"5","key":"bibr1-1533033820947482","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1378\/chest.12-2353","volume":"143","author":"River MP","year":"2013","journal-title":"Chest"},{"issue":"2","key":"bibr2-1533033820947482","first-page":"559","volume":"140","author":"Medford ARL","year":"2011","journal-title":"Chest"},{"key":"bibr3-1533033820947482","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-012-1578-8"},{"key":"bibr4-1533033820947482","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.4.1186"},{"key":"bibr5-1533033820947482","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.869"},{"key":"bibr6-1533033820947482","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840060516"},{"key":"bibr7-1533033820947482","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0637"},{"issue":"3","key":"bibr8-1533033820947482","first-page":"215","volume":"17","author":"Li K","year":"2014","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"bibr9-1533033820947482","doi-asserted-by":"publisher","DOI":"10.1159\/000339507"},{"key":"bibr10-1533033820947482","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyw180"},{"issue":"4","key":"bibr11-1533033820947482","first-page":"596","volume":"7","author":"Chavez C","year":"2015","journal-title":"J Thorac Dis"},{"key":"bibr12-1533033820947482","doi-asserted-by":"publisher","DOI":"10.1159\/000084050"},{"key":"bibr13-1533033820947482","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2506"},{"key":"bibr14-1533033820947482","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31802fbc96"},{"key":"bibr15-1533033820947482","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13151"},{"key":"bibr16-1533033820947482","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12257"}],"container-title":["Technology in Cancer Research &amp; 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