{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:22:08Z","timestamp":1790648528747,"version":"4.1.0"},"reference-count":55,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to investigate the serum inflammatory cytokines levels in patients with COPD, pneumonia and lung cancer, and assess the correlation between the levels of inflammatory cytokines levels and development of these diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Two hundred thirty-two patients including 114 patients with pneumonia, 76 patients with chronic obstructive pulmonary disease (COPD) and 42 patients with lung cancer, and 62 age-matched healthy volunteers as controls were enrolled. The pro-inflammatory cytokine IL-6, IL-2, IFN-\u03b3, TNF-\u03b1, anti-inflammatory cytokines IL-4 and IL-10 in serum were analyzed by flow cytometry microsphere array (CBA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found that the levels of TNF-\u03b1 and IL-10 in patients with lung cancer, COPD and pneumonia were significantly higher than control group. The IL-6 in the lung cancer group were significantly increased compared with the controls and COPD group, pneumonia group. IFN-\u03b3 and IL-2 levels were lower in lung cancer compared with controls and COPD group, pneumonia group. TNF-\u03b1, IL-4 and IL-10 levels were increased in patients with COPD and pneumonia compared with controls. In addition, the concentrations of IFN-\u03b3 and IL-6 were increased in acute exacerbation COPD (AECOPD) group compared with stable COPD group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In conclusion, elevated TNF-\u03b1 and IL-10 levels in serum may be related with lung diseases including lung cancer, COPD and pneumonia. Additionally, IFN-\u03b3 and IL-6 might be potential biomarkers for the further deterioration of lung disease patients. The increased concentrations of IFN-\u03b3 and IL-6 might be used to predict the exacerbation of COPD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533033820951807","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T06:02:20Z","timestamp":1603864940000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Change of Serum Inflammatory Cytokines Levels in Patients With Chronic Obstructive Pulmonary Disease, Pneumonia and Lung Cancer"],"prefix":"10.1177","volume":"19","author":[{"given":"Jian","family":"Chen","sequence":"first","affiliation":[{"name":"Central Laboratory, Longyan First Hospital Affiliated to Fujian Medical University, Longyan, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xincai","family":"Li","sequence":"additional","affiliation":[{"name":"Central Laboratory, Longyan First Hospital Affiliated to Fujian Medical 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