{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:28:46Z","timestamp":1777940926550,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This preliminary simulation study aimed to compare the dosimetric outcomes of carotid arteries (CAs) and pharyngeal constrictor muscle (PCM) in patients with T1N0M0 glottic carcinoma undergoing helical tomotherapy-intensity modulated radiotherapy (HT-IMRT) and 3-dimensional conformal radiotherapy (3D-CRT) plans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In addition to the clinical target volume (CTV) which was defined as the entire larynx, the CAs and PCM of 11 glottic carcinoma patients were delineated. The CTV was uniformly expanded 5 mm to create a planning target volume (PTV) relative to the PCM and at a distance of 2 mm from the CA. The dosimetric characteristics in HT-IMRT and lateral opposed fields-based 3D-CRT plans were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Median D\n                      <jats:sub>95%<\/jats:sub>\n                      and V\n                      <jats:sub>100%<\/jats:sub>\n                      of PTV were significantly higher in HT-IMRT (p &lt; 0.001) compared to 3D-CRT. The right\/left CA dosimetric outcomes, including the mean doses (20.7\/21.5 Gy versus 48.7\/50.5 Gy), D\n                      <jats:sub>max<\/jats:sub>\n                      (53.6\/52.0 Gy versus 67.4\/67.7 Gy), V\n                      <jats:sub>30<\/jats:sub>\n                      (25.0\/27.1% versus 77.6\/80.3%), V\n                      <jats:sub>40<\/jats:sub>\n                      (8.0\/7.9% versus 74.6\/71.9%), and V\n                      <jats:sub>50<\/jats:sub>\n                      (2.0\/1.2% versus 70.0\/71.6%) were also significantly lower in HT-IMRT (p &lt; 0.05), similar to the mean PCM doses (49.6 Gy versus 62.6 Gy for 3D-CRT;p &lt; 0.001), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our present results demonstrated the feasibility of simultaneous sparing of the CAs and PCM in HT-IMRT- compared to 3D-CRT plans in glottic carcinoma patients undergoing definitive radiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533033820956989","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T05:25:22Z","timestamp":1602221122000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Preliminary Simulation Study of Carotid Artery and Pharyngeal Constrictor Muscle Sparing-Radiotherapy in Glottic Carcinoma"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2218-2074","authenticated-orcid":false,"given":"Yurday","family":"Ozdemir","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Baskent University Medical Faculty, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Acibuci","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Baskent University Medical Faculty, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Selek","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey"},{"name":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Topkan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Baskent University Medical Faculty, Adana, 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