{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:29:00Z","timestamp":1777940940891,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>In this study we aimed to identify a set of prognostic factors for angioimmunoblastic T-cell lymphoma (AITL) and establish a novel prognostic model. The clinical data of 64 AITL patients enrolled to the Fourth Hospital of Hebei Medical University (from 2012 Jan to 2017 May) were retrospectively analyzed. The estimated 5-year overall survival and progression-free survival of this cohort of patients were 45.8% and 30.8%, respectively. Univariate analysis showed that age &gt; 60 years, performance status \u22652, Ann Arbor stage III\/IV, lactate dehydrogenase &gt; 250 U\/L, serum albumin (ALB) &lt; 30 g\/l, Coombs test positive, and Ki-67 rate \u2265 70% were significantly associated with poor prognosis. Multivariate analysis demonstrated that age &gt; 60 years, ALB &lt; 30 g\/l, Ki-67 rate \u2265 70%, and Coombs test positive were independent prognosis factors for AITL. Here a new prognostic model, named as AITLI, was constructed using the top 5 significant prognostic factors for AITL prognostic prediction. The AITL patients were stratified into 3 risk groups: low, intermediate, and high risk groups. The new prognostic model AITLI showed better performance in predicting prognosis than the International Prognostic Index (IPI) and the prognostic index for PTCL, not otherwise specified (PIT) that were wisely used to predict the outcome for patients with other subtypes of lymphoma.<\/jats:p>","DOI":"10.1177\/1533033820964231","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T22:11:51Z","timestamp":1603145511000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Development of a Novel Clinical Prognostic Model for Patients With Angioimmunoblastic T-Cell Lymphoma"],"prefix":"10.1177","volume":"19","author":[{"given":"Chen","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huichao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinic Laboratory, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanping","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4589-6475","authenticated-orcid":false,"given":"Lihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"bibr1-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24791"},{"key":"bibr2-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12817"},{"key":"bibr3-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-531509"},{"key":"bibr4-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-644591"},{"key":"bibr5-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.08003.x"},{"key":"bibr6-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181573059"},{"key":"bibr7-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-692541"},{"key":"bibr8-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"bibr9-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3080"},{"key":"bibr10-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"bibr11-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.3647"},{"key":"bibr12-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13393"},{"key":"bibr13-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092585"},{"key":"bibr14-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12484"},{"key":"bibr15-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2013.10"},{"key":"bibr16-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-105759"},{"key":"bibr17-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv237"},{"key":"bibr18-1533033820964231","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1133814"},{"key":"bibr19-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf033"},{"key":"bibr20-1533033820964231","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.525270"},{"issue":"1","key":"bibr21-1533033820964231","first-page":"12","volume":"103","author":"Seung-Sook L","year":"2010","journal-title":"Int J Cancer"},{"key":"bibr22-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-374371"},{"key":"bibr23-1533033820964231","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-016-2010-6"},{"key":"bibr24-1533033820964231","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.476"}],"container-title":["Technology in Cancer Research &amp; 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