{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:29:30Z","timestamp":1777940970086,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the Key Laboratory of High-Incidence-Tumor Prevention & Treatment (Guangxi Medical University), Ministry of Education","doi-asserted-by":"publisher","award":["GKE2018-05"],"award-info":[{"award-number":["GKE2018-05"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To investigate the feasibility of serum extra spindle pole bodies-like 1 (ESPL1) used as a biomarker for patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>131 chronic HBV-infection patients were recruited and divided into HBV S gene integration, non-HBV S gene integration, chronic hepatitis B (CHB), HBV-related liver cirrhosis (LC) and HBV-related HCC group, 24 non-HBV-related HCC patients were selected as HCC control group, 30 people without HBV-infection as healthy control group. Serum ESPL1 were detected and compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>ESPL1 level of integration group was significantly higher than that of non-integration group (346.7 vs 199.6 ng\/ml, P = 0.000) and healthy control group (346.7 vs 41.3 ng\/ml, P = 0.000). ESPL1 level of non-integration group was significantly higher than that of healthy control group (199.6 vs 41.3 ng\/ml, P = 0.000); ESPL1 levels in chronic HBV-infection related groups were increased in turn according to CHB group (95.8 ng\/ml), HBV-related LC group (268.2 ng\/ml), HBV-related HCC group (279.9 ng\/ml) and integration group (346.7 ng\/ml). Except that there was no significant difference in ESPL1 levels between HBV-related LC and HCC group ( P = 0.662), pairwise comparisons between other groups showed significant differences ( P &lt; 0.05). ESPL1 level of HBV-related HCC group was significantly higher than that of non-HBV-related HCC group (279.9 vs 46.6 ng\/ml, P = 0.000), there was no noticeable difference between non-HBV-related HCC and healthy control group (46.6 vs 41.3 ng\/ml, P = 0.848). ESPL1 level of HBV-related HCC group after resection was significantly lower than that of before resection (178.4 vs 260.8 ng\/ml, P = 0.000).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Chronic HBV-infection patients with high ESPL1 level may indicate HBV S gene integration and is a high-risk population for HBV-related HCC. Serum ESPL1 can be used as a biomarker for screening HBV-related HCC high-risk population and monitoring recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1533033820980785","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T09:12:11Z","timestamp":1607937131000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Serum ESPL1 Can Be Used as a Biomarker for Patients With Hepatitis B Virus-Related Liver Cancer: A Chinese Case-Control Study"],"prefix":"10.1177","volume":"19","author":[{"given":"Rongming","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deli","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhang","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huikun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghua","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8961-417X","authenticated-orcid":false,"given":"Jianning","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"bibr1-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"bibr2-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.3055"},{"key":"bibr3-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27735"},{"key":"bibr4-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21176"},{"key":"bibr5-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.001"},{"key":"bibr6-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.08.011"},{"key":"bibr7-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.01.030"},{"key":"bibr8-1533033820980785","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13946"},{"key":"bibr9-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.02.017"},{"key":"bibr10-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1309\/W3XCNT4HKFBN2G0B"},{"key":"bibr11-1533033820980785","volume-title":"The Cell Cycle: Principles of Control","author":"Morgan DO","year":"2010"},{"key":"bibr12-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1038\/nature17402"},{"key":"bibr13-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1002\/embj.201488098"},{"key":"bibr14-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25835"},{"key":"bibr15-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14075"},{"key":"bibr16-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"bibr17-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29913"},{"key":"bibr18-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.016"},{"key":"bibr19-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(14)61215-0"},{"issue":"1","key":"bibr20-1533033820980785","first-page":"88","volume":"62","author":"Dandri M","year":"2015","journal-title":"Minerva Gastroenterologica e Dietologica"},{"issue":"08","key":"bibr21-1533033820980785","first-page":"679","volume":"28","author":"Zang WW","year":"2020","journal-title":"Chinese J Hepatol"},{"key":"bibr22-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.12.014"},{"key":"bibr23-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-015-1126-4"},{"key":"bibr24-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306228"},{"key":"bibr25-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200506119"},{"key":"bibr26-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133769"},{"key":"bibr27-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2454"},{"key":"bibr28-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-014-1458-6"},{"key":"bibr29-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-3070-z"},{"key":"bibr30-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801610105"},{"key":"bibr31-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022167"},{"key":"bibr32-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.12.5386"},{"key":"bibr33-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.07.015"},{"key":"bibr34-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90266-H"},{"key":"bibr35-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-016-0059-2"},{"key":"bibr36-1533033820980785","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03083"}],"container-title":["Technology in Cancer Research &amp; Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533033820980785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1533033820980785","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1533033820980785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:07:11Z","timestamp":1777702031000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1533033820980785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":36,"alternative-id":["10.1177\/1533033820980785"],"URL":"https:\/\/doi.org\/10.1177\/1533033820980785","relation":{},"ISSN":["1533-0346","1533-0338"],"issn-type":[{"value":"1533-0346","type":"print"},{"value":"1533-0338","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]},"article-number":"1533033820980785"}}