{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:29:51Z","timestamp":1777940991665,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81672432"],"award-info":[{"award-number":["81672432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The high fatality-to-case ratio of hepatocellular carcinoma is directly related to metastasis. The signal transducer and activator of transcription-3 is a key mediator of the cytokine and growth factor signaling pathways and drives the transcription of genes responsible for cancer-associated phenotypes. However, so far, no specific inhibitor for signal transducer and activator of transcription-3 has been used in clinical practice. Therefore, targeting the signal transducer and activator of transcription-3 for cancer therapy is highly desired to improve outcomes in patients with hepatocellular carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Design:<\/jats:title>\n                    <jats:p>Using the small-molecule inhibitor NT157, the effect of signal transducer and activator of transcription-3 inhibition on cell migration was tested in hepatocellular carcinoma cell lines and a lung metastasis model of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>NT157 significantly inhibited the migration of hepatocellular carcinoma cell lines in vitro and lung metastasis of hepatocellular carcinoma in vivo. Mechanistically, it inhibited the phospho-signal transducer and activator of transcription-3 in a dose- and time-dependent manner. Furthermore, NT157 treatment suppressed the c-Jun activation domain-binding protein-1 levels in the nucleus but no significant decrease was observed in its expression in the cytoplasm. Finally, high mRNA expression levels of signal transducer and activator of transcription-3 and c-Jun activation domain-binding protein-1 in hepatocellular carcinoma were associated with significantly low survival rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NT157 inhibits hepatocellular carcinoma migration and metastasis by downregulating the signal transducer and activator of transcription-3\/c-Jun activation domain-binding protein-1 signaling pathway and targeting it may serve as a novel therapeutic strategy for the clinical management of hepatocellular carcinoma in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338211027916","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T05:00:41Z","timestamp":1625806841000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["NT157 Inhibits HCC Migration via Downregulating the STAT3\/Jab1 Signaling Pathway"],"prefix":"10.1177","volume":"20","author":[{"given":"SiZhe","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China"},{"name":"Department of Thoracic Medical Oncology, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China"},{"name":"Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KeJia","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenYuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9780-0845","authenticated-orcid":false,"given":"Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong University, Ministry of Education of China, Xi\u2019an, Shaanxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenJuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"bibr1-15330338211027916","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"bibr2-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.103"},{"key":"bibr3-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-014-9522-4"},{"key":"bibr4-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81959-5"},{"key":"bibr5-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5332.1630"},{"key":"bibr6-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.183"},{"key":"bibr7-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80011-4"},{"key":"bibr8-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24567"},{"key":"bibr9-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2674"},{"key":"bibr10-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207378"},{"key":"bibr11-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205260"},{"key":"bibr12-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.404"},{"key":"bibr13-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.07.019"},{"key":"bibr14-15330338211027916","first-page":"9013169","volume":"2019","author":"Zhang M","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"bibr15-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2011.539205"},{"key":"bibr16-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3818"},{"key":"bibr17-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3385"},{"key":"bibr18-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0842"},{"key":"bibr19-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.326"},{"key":"bibr20-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.271"},{"key":"bibr21-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205859"},{"key":"bibr22-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2130"},{"key":"bibr23-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28372"},{"key":"bibr24-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0413-7"},{"key":"bibr25-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0317"},{"key":"bibr26-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1186\/1747-1028-5-26"},{"issue":"11","key":"bibr27-15330338211027916","first-page":"2977","volume":"63","author":"Kouvaraki MA","year":"2003","journal-title":"Cancer Res"},{"key":"bibr28-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3472"},{"key":"bibr29-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.03.015"},{"key":"bibr30-15330338211027916","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2018.09.011"},{"key":"bibr31-15330338211027916","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S156198"},{"issue":"99","key":"bibr32-15330338211027916","first-page":"547","volume":"57","author":"Qin J","year":"2010","journal-title":"Hepatogastroenterology"}],"container-title":["Technology in Cancer Research &amp; Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15330338211027916","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15330338211027916","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15330338211027916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:08:03Z","timestamp":1777702083000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15330338211027916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":32,"alternative-id":["10.1177\/15330338211027916"],"URL":"https:\/\/doi.org\/10.1177\/15330338211027916","relation":{},"ISSN":["1533-0346","1533-0338"],"issn-type":[{"value":"1533-0346","type":"print"},{"value":"1533-0338","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,1]]},"article-number":"15330338211027916"}}