{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:29:58Z","timestamp":1777940998035,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To construct a simplified prognostic risk model to predict overall survival after adjuvant radiotherapy for parotid gland carcinoma patients with stage T1-4aN1-3M0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We evaluated 879 patients who were pathological diagnosed as stage T1-4aN1-3M0 parotid gland cancer. Those eligible patients treated with parotidectomy and neck lymph node dissection between 2004 and 2015 in the Surveillance Epidemiology and End Results database. All cases received adjuvant radiotherapy. Independent prognostic factors included in the original model were identified by Cox regression analysis. The primary endpoint was overall survival. The model\u2019s prediction power was evaluated by the concordance index. The entire cohort was categorized into new low- and high-risk groups using X-tile software according to the results of prognostic model. Kaplan-Meier method was used to depict the survival curves. And the statistical significance was determined by log-rank test. Besides, a heat map was visually described the association between the survival time and 2 most significant prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the univariable and multivariate analyses, 4 independent factors for overall survival were age, tumor size, pTNM stage, and the number of positive lymph nodes, which were all selected in the parsimonious prognostic model. The concordance indices of the prognostic model and pTNM stage were 0.652 and 0.565, respectively. Patients in the low-risk group had better overall survival over patients in the high-risk group [unadjusted hazard ratio = \u20092.578, 95% confidence interval 2.095-3.172, P\u2009 &lt; 0.001]. The results of the heat map revealed that patients with smaller tumor size and fewer positive lymph nodes had much longer survival time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This parsimonious prognostic model could estimate the long-term survival after adjuvant radiotherapy for parotid gland carcinoma with stage T1-4aN1-3N0M0. The tools may be valuable to guide multidisciplinary team in making treatment decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15330338211035257","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T05:06:16Z","timestamp":1627967176000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["A Parsimonious Prognostic Model and Heat Map for Predicting Survival Following Adjuvant Radiotherapy in Parotid Gland Carcinoma With Lymph Node Metastasis"],"prefix":"10.1177","volume":"20","author":[{"given":"Wen-Mei","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Head and Neck surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-6864","authenticated-orcid":false,"given":"Lei-Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan-Ye","family":"Wei","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Long","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jinling Hospital, Nanjing University, Nanjing, Jiangsu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"bibr1-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.09.005"},{"key":"bibr2-15330338211035257","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S192788"},{"key":"bibr3-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0795-0"},{"key":"bibr4-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5637-x"},{"key":"bibr5-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.06.009"},{"key":"bibr6-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930501)71:9<2699::AID-CNCR2820710902>3.0.CO;2-T"},{"key":"bibr7-15330338211035257","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.2.96"},{"key":"bibr8-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1177\/030089160909500406"},{"key":"bibr9-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815594789"},{"key":"bibr10-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24015"},{"key":"bibr11-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1663-2"},{"key":"bibr12-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20279"},{"key":"bibr13-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24631"},{"key":"bibr14-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.02.005"},{"key":"bibr15-15330338211035257","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23546"},{"key":"bibr16-15330338211035257","unstructured":"National Comprehensive Cancer Network. 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