{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:26:08Z","timestamp":1790198768214,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 11805198"],"award-info":[{"award-number":["Grant No. 11805198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["Grant No. WK2030040089"],"award-info":[{"award-number":["Grant No. WK2030040089"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    To compare the dosimetric influence of applicator displacement on two-dimensional brachytherapy (2D-BT) and three-dimensional brachytherapy (3D-BT) for cervical cancer. Nineteen patients who received computed tomography-guided tandem-and-ovoid (T&amp;O) brachytherapy were retrospectively selected. Both 2D (point-based) and 3D (volume-based) plans with and without virtual applicator displacement in the 3 axes were created for each patient. Dose changes at point A, D\n                    <jats:sub>90<\/jats:sub>\n                    of the high-risk clinical target volume (HR-CTV) and intermediate-risk CTV (IR-CTV), and the D\n                    <jats:sub>0.1cc<\/jats:sub>\n                    , D\n                    <jats:sub>1cc<\/jats:sub>\n                    , D\n                    <jats:sub>2cc<\/jats:sub>\n                    , and D\n                    <jats:sub>5cc<\/jats:sub>\n                    of organs-at-risk (OARs) caused by applicator displacement were evaluated. Both 2D-BT and 3D-BT plans were sensitive to T&amp;O applicator displacement. The D\n                    <jats:sub>90<\/jats:sub>\n                    of the CTV and the dose at point A were very sensitive to applicator displacement in the right\u2013left direction ( X-axis). An applicator shift of &gt;2\u2005mm in the X-axis resulted in a change of &gt;5% in the dose at point A and D\n                    <jats:sub>90<\/jats:sub>\n                    of HR-CTV and IR-CTV. In addition, the doses to the OARs were mostly affected by applicator displacement in the anterior\u2013posterior direction ( Z-axis). A displacement of &lt;1.5\u2005mm in the Z-axis was required to avoid a dose change of &gt;10% for OARs. For both 2D-BT and 3D-BT plans, T&amp;O displacement greater than \u2009\u00b1\u20092\u2005mm in the X-axis or T&amp;O applicator displacement \u2009\u00b1\u20091.5\u2005mm in the Z-axis resulted in significant dose changes to the tumor and OARs. In comparison with 3D-BT plans, 2D-BT plans delivered a higher dose to the tumor, and the OARs received more undesirable doses when applicator displacement occurred. The influence of applicator displacement on the doses to the tumor and OARs differed between 2D-BT and 3D-BT. Physicians should take individual patient differences into account when selecting a brachytherapy plan to mitigate the influence of applicator displacement.\n                  <\/jats:p>","DOI":"10.1177\/15330338211041201","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T10:56:59Z","timestamp":1632740219000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of the Dosimetric Influence of Applicator Displacement on 2D and 3D Brachytherapy for Cervical Cancer Treatment"],"prefix":"10.1177","volume":"20","author":[{"given":"Ailin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-6800","authenticated-orcid":false,"given":"Du","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Engineering and Applied Physics, University of Science and Technology of China, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"bibr1-15330338211041201","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.12.015"},{"key":"bibr2-15330338211041201","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2010.06.004"},{"key":"bibr3-15330338211041201","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.11.014"},{"key":"bibr4-15330338211041201","doi-asserted-by":"publisher","DOI":"10.1586\/era.09.166"},{"key":"bibr5-15330338211041201","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.03.010"},{"key":"bibr6-15330338211041201","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.10.032"},{"key":"bibr7-15330338211041201","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140163"},{"key":"bibr8-15330338211041201","doi-asserted-by":"publisher","DOI":"10.1177\/030089160709300505"},{"key":"bibr9-15330338211041201","first-page":"15","volume":"14","author":"Gerszten K","year":"1998","journal-title":"J Brachytherapy Int"},{"key":"bibr10-15330338211041201","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-004-1192-7"},{"key":"bibr11-15330338211041201","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90402-H"},{"key":"bibr12-15330338211041201","doi-asserted-by":"publisher","DOI":"10.1016\/j.radphyschem.2015.11.011"},{"key":"bibr13-15330338211041201","doi-asserted-by":"publisher","DOI":"10.5114\/jcb.2013.39453"},{"key":"bibr14-15330338211041201","volume-title":"Dose and Volume Specification for Reporting Intracavitary Therapy in Gynaecology. 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