{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:12:40Z","timestamp":1787785960857,"version":"build-2784847793"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81530060"],"award-info":[{"award-number":["81530060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81671785"],"award-info":[{"award-number":["81671785"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81874224"],"award-info":[{"award-number":["81874224"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Key Research and Develop Program of China","award":["2016YFC0105106"],"award-info":[{"award-number":["2016YFC0105106"]}]},{"name":"the Shandong Provincial Natural Science Foundation","award":["ZR2016HQ09"],"award-info":[{"award-number":["ZR2016HQ09"]}]},{"name":"the Shandong Provincial Natural Science Foundation","award":["ZR2020LZL001"],"award-info":[{"award-number":["ZR2020LZL001"]}]},{"name":"the Foundation of Taishan Scholars","award":["No.tsqn201909140"],"award-info":[{"award-number":["No.tsqn201909140"]}]},{"name":"the Foundation of Taishan Scholars","award":["ts20120505"],"award-info":[{"award-number":["ts20120505"]}]},{"name":"the Academic promotion program of Shandong First Medical University","award":["2019LJ004"],"award-info":[{"award-number":["2019LJ004"]}]},{"name":"the Academic promotion program of Shandong First Medical University","award":["2020RC003"],"award-info":[{"award-number":["2020RC003"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Objective: To investigate the features of helical tomotherapy and co-planar dual Arcs volumetric-modulated arc therapy during prophylactic cranial irradiation associated with bilateral hippocampal tissue sparing. Materials and methods: Helical tomotherapy and co-planar dual arcs volumetric-modulated arc therapy treatment plans were generated with a dose of 30\u2005Gy\/10 fractions in 16 patients treated with prophylactic cranial irradiation. The dose to the bilateral hippocampal tissues, organs at risk, and planning target volume were determined when the average dose of bilateral hippocampal tissues was reduced by approximately 4\u2005Gy as an observation point. Changes in dosimetry when sparing the bilateral hippocampal tissues were determined for both modalities. Results: When bilateral hippocampal tissues were restricted to 8\u2005Gy, D\n                    <jats:sub>40%mean-bilateral hippocampal tissues<\/jats:sub>\n                    \u2009=\u20097.64\u2009\u00b1\u20090.41\u2005Gy in helical tomotherapy, while D\n                    <jats:sub>40%mean-bilateral hippocampal tissues<\/jats:sub>\n                    \u2009=\u200910.96\u2009\u00b1\u20090.38\u2005Gy in co-planar dual arcs volumetric-modulated arc therapy volumetric-modulated arc therapy. Helical tomotherapy was associated with significantly lower doses to organs at risk, including D\n                    <jats:sub>mean-bilateral hippocampal tissues<\/jats:sub>\n                    ( P\u2009=\u2009.03), D\n                    <jats:sub>98%-bilateral hippocampal tissues<\/jats:sub>\n                    ( P\u2009=\u2009.01), D\n                    <jats:sub>2%-bilateral hippocampal tissues<\/jats:sub>\n                    ( P\u2009=\u2009.01), D\n                    <jats:sub>mean-inner ear<\/jats:sub>\n                    ( P\u2009=\u2009.02), D\n                    <jats:sub>mean-parotid glands<\/jats:sub>\n                    ( P\u2009=\u2009.02), D\n                    <jats:sub>max-lens<\/jats:sub>\n                    ( P\u2009=\u2009.02), and D\n                    <jats:sub>max-brainstem<\/jats:sub>\n                    ( P\u2009=\u2009.02), but not D\n                    <jats:sub>max-optic nerves<\/jats:sub>\n                    ( P\u2009=\u2009.87). Helical tomotherapy provided better target coverage, with lower average D\n                    <jats:sub>2%-PTV<\/jats:sub>\n                    ( P\u2009=\u2009.02), higher average D\n                    <jats:sub>98%-PTV<\/jats:sub>\n                    ( P\u2009=\u2009.02), and better conformal index (0.87 vs 0.84, P\u2009=\u2009.02) and homogeneity index (0.15 vs 0.21, P\u2009=\u2009.05). With smaller bilateral hippocampal tissues doses, the planning target volume dose changed across 3 dosimetry regions for both modalities; the plateau region (&gt;20.0\u2005Gy for helical tomotherapy versus &gt;16.0\u2005Gy for co-planar dual arcs volumetric-modulated arc therapy), gradient region (20.0-12.0\u2005Gy vs 16.0-11.0\u2005Gy), and falling region (&lt;12.0\u2005Gy vs &lt;11.0\u2005Gy). The average delivery duration of helical tomotherapy was almost 7.7 times longer than that of co-planar dual arcs volumetric-modulated arc therapy. Conclusions: Helical tomotherapy was better at sparing the bilateral hippocampal tissues and organs at risk and had better target coverage but a significantly longer treatment duration than co-planar dual arcs volumetric-modulated arc therapy. Further dose decreases in the bilateral hippocampal tissues would yield worse target dose coverage.\n                  <\/jats:p>","DOI":"10.1177\/15330338211043975","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:30:16Z","timestamp":1633912216000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Capabilities and Characteristics of Helical Tomotherapy and Co-Planar  Dual Arcs Volumetric-Modulated arc Therapy Associated with Hippocampal Sparing During Prophylactic Cranial Irradiation"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1464-913X","authenticated-orcid":false,"given":"Dandan","family":"Wang","sequence":"first","affiliation":[{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmin","family":"Ma","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Fu","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabing","family":"Gu","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Bai","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yin","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baosheng","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"},{"name":"Shandong Medical Imaging and Radiotherapy Engineering Technology Research Center, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"},{"name":"Shandong Medical Imaging 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