{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:30:17Z","timestamp":1777941017674,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7212042"],"award-info":[{"award-number":["7212042"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research & Cultivation Fund of Capital Medical University","award":["PYZ20014"],"award-info":[{"award-number":["PYZ20014"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technol Cancer Res Treat"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Background: This presented study was aimed to evaluate the diagnostic and prognostic value of PD-L1\n                    <jats:sup>+<\/jats:sup>\n                    Neutrophils (PD-L1\n                    <jats:sup>+<\/jats:sup>\n                    NEUT) and neutrophil to lymphocyte ratio (NLR) based on our previous experience of Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Treg in transplantation. Methods: the NLR cutoff value of 1.79 was used to include 136 cases from the 204 patients with hepatocellular carcinoma (HCC) confirmed by clinical pathology, which were divided into highly-moderately and poorly differentiated HCC groups. The expressions of PD-L1\n                    <jats:sup>+<\/jats:sup>\n                    NEUT and Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Treg in peripheral blood and cancer tissue were detected with flow cytometry, meanwhile, PD-L1 and Foxp3 expressed in carcinoma and para-carcinoma tissues were marked by immunohistochemistry. Survival rates, including overall survival and disease-free survival, were calculated by the Kaplan\u2013Meier curve and evaluated with the log-rank test. Finally, Cox risk regression model was used to analyze the independent risk factors for prognostic survival. Results: The level of PD-L1\n                    <jats:sup>+<\/jats:sup>\n                    NEUT, Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Treg, and NLR in peripheral blood of patients with poorly differentiated HCC were significantly increased (all P\u2009&lt;\u2009.001). Both PD-L1\n                    <jats:sup>+<\/jats:sup>\n                    NEUT and NLR were positively correlated with Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Treg ( r\u2009=\u20090.479, P\u2009=\u2009.0017; r\u2009=\u20090.58, P\u2009&lt;\u2009.0001). The level of PD-L1\n                    <jats:sup>+<\/jats:sup>\n                    NEUT and Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Treg as well as PD-L1 and Foxp3 in cancer tissue and patients with poorly differentiated HCC were obviously increased (all P\u2009&lt;\u2009.01), respectively. Cox regression analysis indicated that PD-L1\n                    <jats:sup>+<\/jats:sup>\n                    NEUT, NLR, and Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Treg were independent risk factors for the prognosis ( P\u2009=\u2009.000, .000, .006) with a RR and 95%CI of 2.704-(2.155-3.393), 3.139-(2.361-4.173), 1.409-(1.105-1.798), respectively. Conclusion: PD-L1\n                    <jats:sup>+<\/jats:sup>\n                    NEUT, NLR, and Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Treg are independent risk factors for prognosis which maybe new marker of lower survival benefits.\n                  <\/jats:p>","DOI":"10.1177\/15330338211045820","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T03:43:04Z","timestamp":1633405384000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["PD-L1\n                    <sup>+<\/sup>\n                    NEUT, Foxp3\n                    <sup>+<\/sup>\n                    Treg, and NLR as New Prognostic Marker with Low Survival Benefits Value in Hepatocellular Carcinoma"],"prefix":"10.1177","volume":"20","author":[{"given":"Lin","family":"Zhou","sequence":"first","affiliation":[{"name":"Beijing ChaoYang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing ChaoYang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-cheng","family":"Lyu","sequence":"additional","affiliation":[{"name":"Beijing ChaoYang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-chao","family":"Pan","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-jie","family":"Shi","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-sheng","family":"Du","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2434-1275","authenticated-orcid":false,"given":"Qiang","family":"He","sequence":"additional","affiliation":[{"name":"Beijing ChaoYang Hospital, Capital Medical University, Beijing, 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